Blog - Building Blocks

  1. UAA! Discover Aminocoumarinyl Lysine

    We say "UAA"! By genetic code expansion you can incorporate our novel aminocoumarinyl lysine in your favorite protein where it serves you as fluorescent probe or photo-activatable caged lysine.

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  2. Discover TIQ and TIC as Proline Analogs

    Implement our 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (TIQ) and -3-carboxylic acid (TIC) building blocks as proline analogs! Shape your peptide and improve binding and performance!

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  3. PotM: Trifunctionality - A Photocaged Maleimide with Carboxy Function

    Just a flash away! Employ our novel nitroveratryl-maleimido-beta-alanine linker derivate and generate stable thioether conjugates upon spatiotemporally controllable irradiation with UV light!

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  4. New Maillard Products for Peptide Synthesis and Analytics

    Benefit of our latest Maillard Reaction Product additions! Use them as reference standard for quality control and food analysis or synthesize modified peptides for research studies.

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  5. A Triazolecarbaldehyde for Selective N-Terminal Protein Modification

    Looking for methods to selectively modify your peptide’s N-terminus? Discover triazolecarbaldehydes and benefit of mild reaction conditions, high yields, and compatibility with aqueous media.

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  6. PotM: Furan-Crosslinking and 5HP2O as Maleimide Alternative

    Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2Os) as stable alternative to maleimides.

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  7. Hidden Champion – The Tetrahydropyranyl Protective Group

    Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and thiol moieties but rarely used in solid-phase peptide synthesis (SPPS). Discover its advantages, e.g., over O/StBu and Trt.

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  8. Common Side Reactions in Fmoc Solid-Phase Peptide Synthesis

    Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!

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  9. Bioisosteric Argininine Analogs

    Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing Nω-carbamoylated arginine building blocks as bioisosteric arginine analogs.

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  10. Norbornenes – Will You Click Me?

    Proposing norbornenes – strained, bicyclic alkenes for fast, copper-free, biocompatible click-conjugation with tetrazines. Read on for more details on applications and available products!

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