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Fmoc-TmbGly-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-alpha-(2,4,6-trimethoxybenzyl)-glycine // Synonyms: Fmoc-N-(2,4,6-trimethoxybenzyl)-glycine, N-(9-Fluorenylmethyloxycarbonyl)-N-(2,4,6-trimethoxybenzyl)-2-aminoacetic acid
- Product code:FAA3400
- CAS No.:166881-43-2
- Formula:C27H27NO7
- Storage temperature:2-8°C
- Molecular weight:477.51 g/mol
from $68.75
description
Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond. Furthermore Dmb and Tmb amino acids prevent aggregation during solid phase synthesis and can prevent aspartimide formation when it is introduced before an Asp residue. They can also increase peptide cyclization efficiency. Standard coupling protocols can be applied
with reagents such as PyBOP, DIC/HOBt or HATU. Acidic deprotection methods used with Wang resin generate the native sequence.
references
N,O-bisFmoc derivatives of N-(2-hydroxy-4-methoxybenzyl)-amino acids: Useful intermediates in peptide synthesis; T. Johnson, M. Quibell, R. C. Sheppard; J. Pept. Sci. 1995; 1(1): 11-25. https://doi.org/10.1002/psc.310010104.
Innovation and perspectives in solid phase synthesis: peptides, proteins and nucleic acids, biological and biomedical applications; J. F. Kennedy, C. J. Knill; edited by R. Epton; Mayflower Scientific Ltd 1995; 71. https://doi.org/10.1002/pi.1995.210380416.
Proceeding of the 24th EPS; K. Jauch et al; edited by R. Ramage, R. Epton; Mayflower Scientific Ltd 1996; 497.
All-L-Leu-Pro-Leu-Pro: a challenging cyclization; M. El Haddadi, F. Cavelier, E. Vives, A. Azmani, J. Verducci, J. Martinez; J. Pept. Sci. 2000; 6(11): 560-570. https://doi.org/10.1002/1099-1387(200011)6:11<560::AID-PSC275>3.0.CO;2-I.
Efficient synthesis and comparative studies of the arginine and Nomega,Nomega-dimethylarginine forms of the human nucleolin glycine/arginine rich domain; S. Zahariev, C. Guarnaccia, F. Zanutin, A. Pintar, G. Esposito, G. Marviæ, B. Krust, A. G. Hovanessian, S. Pongor; J. Pept. Sci. 2005; 11(1): 17-28. https://doi.org/10.1002/psc.577.
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