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Building Blocks
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Carbamidomethylated Cysteine as SPPS Building Block
Our building block Fmoc-L-Cys(Cam)-OH enables peptides resembling reduced and carbamido-methylated protein fragments by standard SPPS without error-prone modification reactions.
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PotM: Plant-Derived Cholesterol for LNP Drug Delivery
Plant-derived Cholesterol of high and consistent product quality in accordance with Pharmacopoeia requirements to replace established animal source material in LNP formulation. Read on!
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CliCr® - a Reactive and Soluble Bioorthogonal Click Reagent
Building blocks with a strained triple bond do not require copper catalysis when used in click chemistry. Discover CliCr®: improved solubility in aqueous conditions and high reactivity! Click here!
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Fatty Di-Acids
Peptide therapeutics – fewer injections/lower doses by prolonging their half-life via addition of a lipid modification that promotes binding to serum proteins such as albumin. Read on for recent innovations!
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Maleimide Crosslinkers
Maleimides provide versatile options for connecting payloads to proteins and other biomolecules. Discover how our bifunctional thiol reactive crosslinkers can support your project. Read on!
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PotM: Perfluorobiphenyl Building Blocks for Site-Selective Cysteine Conjugation
Herein, we present functionalized perfluorobiphenyl building blocks which can be used for site-selective π-clamp mediated cysteine conjugation. Read on for more details about this general method!
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PotM: Argpyrimidine Building Block for SPPS
Argpyrimidine is the result of a Maillard Reaction-like nonenzymatic posttranslational modification. You want to investigate the effect of this change on function and stability? Get the building block!
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PotM: CliCr® - an innovative click reagent
Herein, we present CliCr® as an innovative cyclic alkyne for metal-free strain-promoted click chemistry. Read our blog for detailed information about CliCr® reagents based on TMTHSI and check out available derivatives!
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Acylation Efficiencies on Ser and Thr Pseudoproline Monomers
In two joint studies together with Prof. F. Albericio we investigated the coupling efficiencies of Ser and Thr pseudoproline monomers and their use for the synthesis of inaccessible peptide sequenes. Read on!
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Abraligabra - Reagents and Building Blocks for Chemical Ligation
We can’t get enough of new products and innovations! Read this blog to get detailed information on the cyanylating reagent NTCB as well as selenocysteine amino acids, both useful tools for peptide ligation.
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