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Product Focus
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Photo-Linker for Peptide Amides and Acids
Peptide linkers usually are cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry.
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Getting Bulky
Bulky glycine analogs are interesting molecules for creating peptide derivatives with certain biological activities, e.g. with antiviral properties. Furthermore, they are useful compounds for protein structure evaluation.
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New: Guanidino-Glycine
Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.
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New: Oxazole expanded Glycines
Visit our Glycine section and find a series of amino acid derivatives, where oxazole is the characteristic structural element carrying carboxy and amino function.
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New: Oligo Glycine – Linker
Oligo-glycines are either flexible linkers or form well defined rigid substructures. We offer a variety of oligo-glycines as building blocks which can easily be introduced into any molecule.
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New Statin Analogues: Super-Threonine Derivatives
A set of new statin analogues, so called Super-Threonines, is available consisting of Fmoc protected L-enantiomers with all possible 4 stereoisomers of chiral centers in the side chain. They appear in nature as bridge building element in cyclodepsipeptides, like pipecolidepsin A, a compound which shows relevant cytotoxic activity in three human tumor cell lines (lung, colon, breast) and has unique structural features.
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4-Methylbenzhydryl-Resins - the Better Wang-Resin alternative
Wang resins are widely used for peptide synthesis. However, certain side reactions, like diketopiperazin formation limit their use. 4-Methylbenzhydryl resin needs more space and leaves less room for this type of side reactions. Standard “Wang-typical” Fmoc/tBu coupling protocols can be applied.
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New: Cysteine-Pseudoproline
Pseudoprolines derived from Serine and Threonine have developed to standard building blocks for peptide synthesis since their invention. Now this technology is also available with Cysteine residues, as the corresponding 2,4-dimethoxyphenyl-pseudothiaproline is compatible with standard Fmoc/tBu protocols.
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Amino Aldehydes
Aldehydes are between alcohols and carboxylic acids with respect to their oxidation level and show specific reactivity. Therefore they are highly interesting building blocks and intermediates for a large number of very interesting classes of reactions and compounds such as Wittig reaction, formation of secondary alcohols, heterocycles and semiaminals to name only a few.
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Improved Synthesis with Dmb-Glycine Dipeptide Building Blocks
Positions next to Glycine are often reasons for side reactions, as aspartamide or diketopiperazine formation can occur. Dmb and Tmb can be used for temporary protection of the amide nitrogen of a peptide bond, in order to solubilize the peptide and increase yield and purity.
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