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Product Focus
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Hydrazone Resins as Alternative to SEA Resins
Discover the versatile applications of hydrazone resins e.g. for the preparation of peptide hydrazides, or the generation of peptide thio esters. Read on to find out more and see our available products.
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Maillard Reaction Products – General Advice for Usage, Reconstitution and Storage
Read on for more information about the right handling of Maillard Reaction Products (MRPs), which are frequently used as analytical standards related to food quality and disease processes.
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Protease Stable Ile/Leu Surrogates
Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.
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Measures to Prevent Aspartimide Formation
Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.
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N-Alkyl Substituted Carboxy Linkers for Peptide Synthesis
Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.
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Avoiding Racemization: Fmoc-Aaa-MPPAs as Alternatives for Wang Linker during SPPS
Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.
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Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala
The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.
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Trifluoromethylated Amino Acids
The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!
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Clicky Acids – Fatty Acids for Click Conjugation
Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!
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About the Advantages of Pseudoproline Dipeptides
Serine- and Threonine-derived oxazolidines as well as Cysteine-derived thiazolidines, so-called Pseudoprolines, serve as structure-disrupting, solubilizing building blocks in peptide synthesis.
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