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Linkerology
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The Dawson Linker
The Dawson Linker and its variants provide access to C-terminal peptide thioesters which are crucial components of Native Chemical Ligation reactions. Read on to discover all derivatives available at Iris Biotech!
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pH-Sensitive Self-Immolative Linkers
Are you active in the field of antibody drug conjugates? Click here to find out more about our selection of as well as the technology behind pH-sensitive self-immolative linkers.
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PotM: Proteolysis Targeting Chimeras (PROTACs®)
Drug the undruggable – click here to get more information about the use of PROteolysis TArgeting Chimeras (PROTACs®) as a tool for targeted protein degradation and discover available building blocks.
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Fatty Acid Building Blocks
We are providing variously functionalized, protected and unprotected fatty acid derivatives suitable for SPPS and further conjugation, e.g. via Click chemistry. Read on to discover our portfolio.
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Chemically Tunable Kinetics of Self-Immolation
Discover our selection of disulfide-based self-immolative linkers allowing to influence linker stability, fine-tune the self-immolative cleavage rate and thus impact the speed of the payload release.
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PotM: Substrates for Fusion (Halo/Snap/Clip)-Tagged Proteins
Discover our selection of substrates for Halo-, Snap-, and Clip-tagged proteins bearing different terminal groups suitable for further functionalization, e.g. biotinylation and Click chemistry.
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N-Methylation of Amino-PEG-Acids
Herein we are reporting on the linker stability of amino-PEG-acids achieved via N-methylation and the possible side-reaction without this additional modification. Read on to find out more!
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Haloalkane Dehalogenase Substrates
Discover our selection of Halo ligands as haloalkane dehalogenase substrates, bearing different terminal functional groups suitable for further conjugation, e.g. via Click chemistry.
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N-Alkyl Substituted Carboxy Linkers for Peptide Synthesis
Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.
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Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala
The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.
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