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Linkerology
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His-Tag for Specific Linker Attachment
Learn, how His-Tag can be used for specific linker attachment. Another example in our LINKEROLOGY series of sophisticated linker technologies.
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Product of the Month: Dde-based Linkers
Placing Dde as one terminal group of a linker and a functional group prone for conjugation as the other or using Dde as the central connective portion of a linker, allows for the creation of new bifunctional linkers.
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Subject Focus: Linkerology
The ever-growing sophistication and variation in linker design have given rise to a new and distinct field of knowledge in synthetic chemistry termed Linkerology. Discover our expertise and panoply of new cutting-edge tailor-made linker constructs for the latest state-of-the-art bioconjugations.
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Cleavable Bifunctional Biotin-Linkers
Biotinylation of proteins and their purification via Streptavidin beads is a widely applied method.
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The Safety-Catch Acid-Labile (SCAL)-Linker
The SCAL linker offers superior chemical stability and permits a variety of orthogonal solid-phase approaches. It is fully compatible with the Fmoc-, Boc- and Alloc- strategies. Cleavage can be performed either by a simultaneous, or by a two-step reduction/acidolysis procedure to afford peptide amides.
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3rd Generation Click Chemistry: Tetrazine and TCO Derivatives for Copper-free Conjugation
The reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.
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Photo-Linker for Peptide Amides and Acids
Peptide linkers usually are cleaved under acidic conditions or using two-step procedures. Photocleavage proceeds under neutral conditions using UV light and can either be performed in batch or using flow chemistry.
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Linkers for Antibody-Drug Conjugation (ADC)
Cleavable dipeptide linkers like Val-Ala and Val-Cit rely on processes inside the cell to liberate the payload, as they undergo rapid hydrolysis in the presence of lysosomal extracts or purified human cathepsin B.
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New Click Linker
Click chemistry has developed to a widely used conjugation technique. Here are our latest developments of new short linker for hydrophilic and hydrophobic applications.
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Phthalimidooxy PEG-based cross linkers
Phthalimidooxy PEG-based cross linkers form stable oximes with aldehydes, also latent ones as present in carbohydrates. Their reactivity is sufficiently mild for a broad used in creating conjugates with sensitive biologics.
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