News

Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.

  1. Msbh, a Safety Catch Cysteine Protecting Group for the Synthesis of Cyclic Peptides

    The regioselective formation of multiple disulfide bonds is often a synthetic challenge. We now offer an innovative safety-catch Cys protecting group that allows selective deprotection of the sulfhydryl group and is a valuable addition to the peptide chemist’s toolbox.

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  2. Chlorotoxin & Biotin-Chlorotoxin

    Chlorotoxin is a chloride channel blocker which has been found in the venom of the Egyptian scorpionLeiurus quinquestriatus.

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  3. 3rd Generation Click Chemistry: Tetrazine and TCO Derivatives for Copper-free Conjugation

    The reaction between a tetrazine (Tz) and a trans-cyclooctene (TCO) is the innovative third generation Click reaction that proceeds without the use of copper or other catalyst. It is rapid, fully bioorthogonal and excels at very low concentrations.

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  4. Fast and Easy Protease Kinetics with Asymmetric Rhodamine 110 Substrates

    Asymmetric Rhodamine 110 protease substrates are used for the determination of protease kinetics. The asymmetric structure of these dyes greatly simplifies the determination of enzyme kinetics, while the properties of Rhodamine 110 facilitate an uncomplicated readout.

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  5. THPTA: Ligand-accelerated Click Chemistry in Aqueous Solution

    Polytriazole ligands such as THPTA accelerate the copper-catalyzed azide-alkyne cycloaddition (CuAAC), or “Click”, reaction. Moreover, with the use of further additives, polytriazoles facilitate CuAAC even in live cells by significantly lowering the bioavailability of the copper catalyst.

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  6. Markers for the Quality of Food

    Maillard Reaction Products (MRPs) result from the reaction of Arg and Lys side chains with reducing carbohydrates. MRPs are valuable markers for food quality and are used in many different branches of industry such as food, pharma, cosmetics and biochemistry.

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  7. Furyl-Alanine: A Novel Photo-Click Amino Acid

    2-Furyl-alanine can be incorporated into peptides via SPPS or by using enzymatic approaches. UV-irradiation in the presence of oxygen and a photosensitizer converts furyl-alanine to an intermediate that selectively reacts with certain nucleophiles. This property can be employed for site-specific labeling of peptides and proteins.

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  8. Targeted and Reversible Biotinylation with Biotin-SS-Tyramide

    Our new Biotin-SS-Tyramide linker is a valuable tool for peroxidase-promoted targeted protein biotinylation. By using peroxidase-tagged antibodies, proteins and protein clusters can be selectively biotinylated, and then isolated using streptavidin. The biotin tag can be subsequently removed using reducing agents (e.g. glutathione).

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  9. Fmoc-Phe-Aca: Fluorescent Internalization Reporter for Cell Penetrating Peptides (CPPs)

    The Fmoc-L-Phe-Aca pseudo-dipeptide is a useful reporter group for the successful internalization of CPPs. Phe quenches the fluorescence of Aca. Internalization of the peptide containing Phe-Aca leads to proteolytic cleavage of the Phe-Aca bond and thus to fluorescence.

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  10. Inexpensive & High Quality Guanylation Reagents

    We now offer N,N'-Bis-Boc-N"-triflylguanidine, at both a very competitive price and our habitual high quality. Find out about the usefulness of this and our other guanylation reagents!

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