Blog

  1. Measures to Prevent Aspartimide Formation

    Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.

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  2. PotM: Functionalized Biotinylation Reagents

    Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.

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  3. N-Alkyl Substituted Carboxy Linkers for Peptide Synthesis

    Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.

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  4. Avoiding Racemization: Fmoc-Aaa-MPPAs as Alternatives for Wang Linker during SPPS

    Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.

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  5. Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala

    The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.

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  6. Trifluoromethylated Amino Acids

    The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!

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  7. PotM: Methanoprolines and Dimethylprolines - Constraining the Conformation of Peptides

    Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.

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  8. Innovative ways to fight SARS-CoV-2

    With the approval of several COVID-19 vaccines and drugs in recent months, hope is growing that the current pandemic will end soon.

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  9. RICT 2021

    July 7th - 9th, 2021

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  10. Clicky Acids – Fatty Acids for Click Conjugation

    Iris Biotech offers various (protected) azide- and alkyne-modified fatty acid derivatives suitable for Click Chemistry. Interested? Read on to find out more!

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