New Substituted Ornithine Derivatives

Published on 10/11/2015

l-Ornithine derivative containing peptides play important roles in SAR studies, enzyme inhibition and cancer research. We now offer a variety of N^δ-substituted ornithines containing heterocyclic, aromatic and aliphatic groups, as well as N-substituted C3- and C4-analogs of ornithine.

l-Ornithine derivative containing peptides play important roles in SAR studies, enzyme inhibition, and cancer therapy. Ornithine is produced from arginine by the enzyme Arginase as part of the urea cycle. Some organisms, such as the Gram-negative Vibrio spp., incorporate ornithine into their proteins.

(http://ureacycle.cnmcresearch.org/otc/index.html)

We now offer different N^δ-substituted ornithines containing heterocyclic, aromatic and aliphatic groups, as well as N-substituted C3- and C4-analogs of ornithine.

→ Our portfolio encompasses 68 different Ornithine building blocks as well as 166 Lysine building blocks and 76 Diamino Butyric Acid (Dab) variants and 91 Diamino Propionic Acid (Dap) variants.

→ If you require a building block we do not have in our catalogue, our Custom Synthesis team will be happy to provide you with a noncommittal quote.

References

Toward Understanding the Cationicity of Defensins: ARG AND LYS VERSUS THEIR NONCODED ANALOGS; G. Zou, E. de Leeuw, C. Li, M. Pazgier, C. Li, P. Zeng, W.-Y. Lu, J. Lubkowski and W. Lu; Journal of Biological Chemistry 2007; 282: 19653-19665. doi:10.1074/jbc.M611003200