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H-L-Phe(4-CH2-N3)*HCl
Chemical name: 4-azidomethyl-L-phenylalanine hydrochloride // Synonyms: H-Phe(4-CH2-N3)*HCl, para-methylazido-L-phenylalanine hydrochloride, para-azidomethyl-L-phenylalanine hydrochloride, pAMF*HCl, pN3CH2Phe*HCl,(S)-2-amino-3-(4-(azidomethyl)phenyl)propanoic acid hydro chloride, CAS 2517638-29-6
- Product code:HAA4090
- CAS No.:1446772-80-0
- Formula:C10H12N4O2*HCl
- Storage temperature:2-8°C
- Molecular weight:220,23*36,45 g/mol
- Purity :min. 98%
- Enantiomeric Purity:min. 99,7%
from €84.00
description
This material is used in antibody drug conjugates as a superior SPAAC reaction partner in comparison to H-Phe(4-N3). It can serve as a vibrational reporter of local protein environments after genetic incorporation into proteins.
references
Production of Site-Specific Antibody–Drug Conjugates Using Optimized Non-Natural Amino Acids in a Cell-Free Expression System; Erik S. Zimmerman, Tyler H. Heibeck, Avinash Gill, Xiaofan Li, Christopher J. Murray, Mary Rose Madlansacay, Cuong Tran, Nathan T. Uter, Gang Yin, Patrick J. Rivers, Alice Y. Yam, Willie D. Wang, Alexander R. Steiner, Sunil U. Bajad, Kalyani Penta, Wenjin Yang, Trevor J. Hallam, Christopher D. Thanos, and Aaron K. Sato; Bioconjugate Chem. 2014; 25(2): 351–361. DOI: 10.1021/bc400490z.
Sensitive, Site-Specific, and Stable Vibrational Probe of Local Protein Environments: 4-Azidomethyl-l-Phenylalanine; Christopher G. Bazewicz, Melanie T. Liskov, Kevin J. Hines, and Scott H. Brewer; J. Phys. Chem. B 2013; 117(30): 8987–8993. DOI: 10.1021/jp4052598.
Molina, Arturo PCT Int. Appl. 2019; WO 2019023316 A1.
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