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Fmoc-Gly-MPPA
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-glycine-3-(4-oxymethylphenoxy)propionic acid // Synonyms: 3-(4-((((((9H-fluoren-9-yl)methoxy)carbonyl)glycyl)oxy)methyl)phenoxy)propanoic acid, N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycine-[4-(2-carboxyethoxy)phenyl]methyl ester
- Product code:LW00802
- CAS No.:130914-04-4
- Formula:C27H25NO7
- Storage temperature:2-8°C
- Molecular weight:475,50 g/mol
from €75.00
description
This Fmoc-amino acid-MPPA linker serves as precursor for the linkage to e.g. aminomethyl supports by standard coupling procedures. By this method, a low (max 0.5%) and reproducible epimerization level of the C-terminal amino acid in your peptide is guaranteed.
references
Improved approach for anchoring Nalpha-9-fluorenylmethyloxycarbonylamino acids as p-alkoxybenzyl esters in solid-phase peptide synthesis; F. Albericio, G. Barany; Int. J. Peptide. Protein. Res. 1985; 26(1): 92-97. https://doi.org/10.1111/j.1399-3011.1985.tb03182.x.
Amino acid derivatives used as agents bonding to a solid support; NeoMPS S.A. 2005; French Patent Application FR 0402973, International Patent Application WO2005/095332.
Synthesis of Natural Cyclopentapeptides Isolated from Dianthus chinensis; S. Zhang, Z. Amso, L. M. De Leon Rodriguez, H. Kaur, M. A. Brimble; J. Nat. Prod. 2016; 79(7): 1769-1774. https://doi.org/10.1021/acs.jnatprod.6b00152.
Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G; Z. Amso, R. Kowalczyk, Y.-E. Park, M. Watson, J.-M. Link, D. S. Musson, J. Cornish, M. A. Brimble; Org. Biomol. Chem. 2016; 14: 6231-6243. https://doi.org/10.1039/C6OB00983B.
Synthesis and biological evaluation of the osteoblast proliferating cyclic peptides dianthins G and H; H. Kaur, A. M. Heapy, R. Kowalczyk, Z. Amso, M. Watson, J. Cornish, M. A. Brimble; Tetrahedron 2014; 70(42): 7788-7794. https://doi.org/10.1016/j.tet.2014.04.035.
Synthesis of the Antifungal Cyclic Peptides Tunicyclins C and D; H. Kaur, A. M. Heapy, M. A. Brimble; Synlett 2012; 2: 275-277. https://doi.org/10.1055/s-0031-1290071.
Synthesis of monolysyl advanced glycation endproducts and their incorporation into collagen model peptides; T. M. Woods, M. Kamalov, P. W. R. Harris, G. J. S. Cooper, M. Brimble; Org. Lett. 2012; 14(22): 5740-5743. https://doi.org/10.1021/ol302745f.
Gly/Lys-containing peptide macrocycles: Synthesis and cyclization studies; E. Crusi, J. M. Huerta, D. Andreu, E. Giralt; Tetrahedron Lett. 1990; 31(29): 4191-4194. https://doi.org/10.1016/S0040-4039(00)97579-8.
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