Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Quick contact
Please send me more information about
Mal-D-Dap(Boc)-OH*DCHA
Chemical name: N-alpha-MaleimidoN-beta-t-butyloxycarbonyl-D-2,3-diaminopropionic acid dicyclohexylamine // Synonyms: Mal-D-Dpr(Boc)*DCHA
- Product code:MAA1060
- CAS No.:2382651-11-6 net
- Formula:C12H16N2O6*C12H23N
- Storage temperature:2-8°C
- Molecular weight:284,27*181,32 g/mol
- Purity :min. 99%
- Enantiomeric Purity:min. 99,7%
from €90.00
description
Building block, which can be used for conjugation with thiol groups. After removal of the Boc protecting group and conjugation with the mercaptane function the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and maleimid is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components, like in antibody-drug conjugation (ADC).
references
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R.P. Lyon, J.R. Setter, T.D. Bovee, S.O. Doronia, J.H. Hunter, M.E.
Anderson, C.L.Balasubramanian, S.M. Duniho, C.I. Leiske, F. Li, P.D. Senter; Nature Biotechnology. 2014; 32(10): 1059-1062. Doi:10.1038/nbt.2968.
Do you need further information about this product?
get in contact
Brochures & Flyers
We found other products you might like!
