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Oleyl-PSar15
Chemical name: Oleyl-polysarcosine(15) // Synonyms: (Z)-N-(octadec-9-en-1-yl) polysarcosineamide(15)
- Product code:PSR1930
- Storage temperature:-20°C
- Molecular weight:1000-1500 Da
from €290.00
description
Nucleic acids have emerged in recent years as promising drug candidates for a wide range of diseases, as demonstrated by the development of mRNA vaccines to combat the Covid-19 pandemic. As nucleic acids are unable to pass physiological barriers, novel tools for packaging and delivery are required, especially since the frequently used polyethylene glycol may induce the generation of anti-PEG antibodies, leading to immunogenicity and allergic reactions. Iris Biotech offers a selection of innovative lipidated PSar and PGA-based polyamino acids for improved drug delivery.
SURPAX™ Technology (Surface Pacifying Excipient) was originally designed for protein stabilization but has found additional application as a shielding lipid in LNP formulations. This product shows superior properties for antibody and protein stability, does not impact binding, and maintains activities of mAB to targets. Biocompatibility has been tested vs body weight gain, vein tolerance, biochemical profile, and hematology.
references
US Patent 11,692,099
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