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ICG-mal
Chemical name: Indocyanine green maleimide // Synonyms: 4-(2-((1E,3E,5E,7E)-7-(3-(6-(2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethylamino)-6-oxohexyl)-1,1-dimethyl-1H-benzo[e]indol-2(3H)-ylidene)hepta-1,3,5-trienyl)-1,1-dimethyl-1H-benzo[e]indolium-3-yl)bu tane-1-sulfonate
- Product code:RL-2820
- CAS No.:2143933-81-5
- Formula:C51H56N4O6S
- Storage temperature:-20°C
- Molecular weight:853,09 g/mol
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description
Indocyanine green (ICG) is a near-infrared fluorescence imaging dye. Absorption maximum is at 800 nm and there is slight absorption in the visible range, which results in low auto-fluorescence and tissue absorbance. Emission maximum is at 810 nm. The maleimide groups binds specifically to thiol groups from solvent accessible cysteines on various substrates (antibodies, proteins, peptides, enzymes) and small molecules. ICG has been approved by the FDA and has been found in numerous applications in therapeutics and diagnostics, like: detection of solid tumors, localization of lymphnodes, visualization of retinal and choroidal vasculature, angiography during reconstructive surgery. ICG can be used as imaging dye and as a hyperthermia agent.
references
1. The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. Boudewijn E. Schaafsma MD, J. Sven D. Mieog MD, Merlijn Hutteman MSc, Joost R. van der Vorst MD, Peter J.K. Kuppen PhD, Clemens W.G.M. Löwik PhD, John V. Frangioni MD, PhD, Cornelis J.H. van de Velde MD, PhD, Alexander L. Vahrmeijer MD, PhD; Surg. Oncol. 2011; 104: 323-332. DOI: 10.1002/jso.21943.
2. Degradation kinetics of indocyanine green in aqueous solution. Vishal Saxena, Mostafa Sadoqi, Jun Shao; J. Pharm. Sci. 2003; 92: 2090-2097. DOI: 10.1002/jps.10470.
3. Stability assessment of indocyanine green within dextran-coated mesocapsules by absor- bance spectroscopy. Mohammad Abbas Yaseen; Jie Yu; Michael S. Wong; Bahman Anvari; Journal of Biomedical Optics 2007; 12(6): 064031. DOI:10.1117/1.2821423.
4. H-Type Dimer Formation of Fluorophores: A Mechanism of Activatable In Vivo Optical Molecular Imaging. Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke and Hisataka Kobayashi; ACS Chem. Biol. 2009; 4(7): 535-546. DOI: 10.1021/cb900089j.
In vivo Molecular Imaging of Cancer with a Quenching Near-Infrared Florescent Probe Using Conjugates of Monoclonal Antibodies and Indocyanine Green. Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke, and Hisataka Kobayashi; Cancer Res. 2009; 69(4): 1268-1272. DOI: 10.1158/0008-5472.
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