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Azide-PEG(4)-SNAP
Chemischer Name: N-(4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)-1-azido-3,5,7,9-tetraoxadodecan-12-amide // Synonyme: Azide-PEG-SNAP, Azide-PEG-Benzylguanine, Azide-PEG-BG, Azide-PEG(4)-Benzylguanine, Azide-PEG(4)-BG
- Art-Nr.:RL-3960
- Lagertemperatur:-20°C
- Formel:C24H33N9O6
- Molare Masse:543,59 g/mol
Ab 300,00 €
description
Azide conjugated benzylguanine (BG). The BG moiety reacts specifically and rapidly with the so-called SNAP-tag, a polypeptide protein tag, allowing irreversible and covalent labeling of SNAP fusion proteins with an additional azide functionality suitable for further conjugation via Click Chemistry.
The additional PEG moiety increases overall solubility.
references
Yeast Three-Hybrid Screening for Identifying Anti-Tuberculosis Drug Targets; S. Moser, K. Johnsson; ChemBioChem 2013; 14(17): 2239-2242. https://doi.org/10.1002/cbic.201300472
A yeast-based screen reveals that sulfasalazine inhibits tetrahydrobiopterin biosynthesis; C. Chidley, H. Haruki, M. Grønlund Pedersen. E. Muller, K. Johnsson; Nat. Chem. Biol. 2011; 7: 373-383. https://doi.org/10.1038/nchembio.557
Caged Substrates for Protein Labeling and Immobilization; S. Banala, A. Arnold, K. Johnsson; ChemBioChem 2008; 9(1): 38-41. https://doi.org/10.1002/cbic.200700472
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