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Protease Stable Ile/Leu Surrogates
Herein we are presenting 2-(Fmoc-amino)-3,3-diMe-pent-4-enoic acid (FAA5040), a protease stable Ile/Leu surrogate suitable for further modification via its side chain double bond.
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Measures to Prevent Aspartimide Formation
Aspartimide formation remains one major hurdle during peptide synthesis. Read on to find out more about different strategies and available products at Iris Biotech in order to avoid this side product.
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PotM: Functionalized Biotinylation Reagents
Iris Biotech offers a variety of (functionalized) biotin and desthiobiotin reagents reactive towards certain functional groups. Discover our growing portfolio and latest additions.
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N-Alkyl Substituted Carboxy Linkers for Peptide Synthesis
Herein, we present Fmoc-protected N-alkyl-substituted carboxy linkers, which can be elongated by Fmoc-SPPS and can easily be linked to amino-functionalized solid supports. Read on to find out more about their advantages.
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Avoiding Racemization: Fmoc-Aaa-MPPAs as Alternatives for Wang Linker during SPPS
Compounds of the shown formula can simply be bound to solid supports via amide bond formation without racemization of the C-terminal amino acid and enable the synthesis of very pure peptides.
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Enzymatically Cleavable Linkers Based on Val-Cit and Val-Ala
The peptide-based ADC linkers Val-Cit and Val-Ala are efficiently cleaved by lysosomal proteases and benefit from increased serum stability and effective payload-release in targeted cells.
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Trifluoromethylated Amino Acids
The incorporation of alpha-trifluoromethyl substituted amino acids into peptides increases proteolytic stability, enhances lipophilicity, and induces secondary structures. Read on to find out more!
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PotM: Methanoprolines and Dimethylprolines - Constraining the Conformation of Peptides
Interested in structure-activity studies of your Proline-containing peptide drug? Find out more about the use of Methanoprolines and Dimethylprolines as conformational amide locks.
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