Blog | Page 27

26/01/2021

PotM: Disulfide-Based Self-Immolative Linkers

The linkage of a drug to its carrier via a disulfide-based self-immolative linker allows for the specific intracellular release of the active molecule upon glutathione reduction and linker cleavage.

PotM: Disulfide-Based Self-Immolative Linkers

News Linkerology Knowledge Base

21/01/2021

Linkerology

Check out our latest video summarizing our capabilities and knowledge on linker technologies

Dates & Exhibitions

12/01/2021

VIRTUAL BPS

January 19, 2021

News Building Blocks Product Focus

11/01/2021

New Dawson Linker Derivatives

Interested in the formation of peptide thioesters for Native Chemical Ligation? Read on to find out more about the use of Dawson Linker derivatives as thioester surrogates compatible with Fmoc SPPS.

News Amino Acids Product Focus

11/01/2021

Amino-Methylcoumarins as Fluorescent Labels

Enzymatically-activatable probes based on 7-amino-4-methylcoumarin (AMC) represent versatile tools for the detection and localization of proteolytic enzyme activities. Read on to find out more.

Amino-Methylcoumarins as Fluorescent Labels

News Amino Acids Product Focus

08/12/2020

Modifications of Methionine

Methionine is particularly prone to oxidation by atmospheric oxygen in vitro but also by reactive oxygen species in vivo, resulting in the corresponding sulfoxide and sulfone. Read on to find out more.

News Product of the month Amino Acids

08/12/2020

Product of the Month: Fluorinated Amino Acids

One approach for the design of bioactive peptides with improved pharmacological properties is the derivatization of amino acid building blocks with fluorine. Find out more about the advantages of fluorinated peptides.

Product of the Month: Fluorinated Amino Acids

News Linkerology Building Blocks Product Focus

25/11/2020

Thiol-reactive Linkers for ADCs

The thiosuccinimide linkage is a prominent connective motif resulting from the reaction of a thiol and an alkyl maleimide. Read on to learn more about its applications and potential improvements.

News Product of the month Life Sciences

24/11/2020

Product of the Month: Fluorescent SARS-CoV-2 Protease Substrates

Mpro is a key enzyme of coronaviruses (coronaviridae) and thus an attractive drug target. Iris Biotech offers fluorescent substrates, which can be used to perform various types of screenings and to identify potential inhibitors of COVID-19.