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4-Azido-L-homoalanine

H-L-Aha-OH*HCl
H-L-Dab(N3)-OH

4-Azido-L-homoalanine
(S)-2-Amino-4-azidobutanoic acid hydrochloride

Formula:                    C4H8N₄O₂*HCl
Molecular Weight:     144,13*35,45 g/mole

CAS:  942518-29-8

CODE:  HAA5730

1g:       EUR    200,-    US$    300,- 
5g:       EUR    800,-    US$  1200,-

Prices are in EUR, net, exw Germany, shipping not include

Cross-Linker: Mal-AMCHC-OSu

Mal-AMCHC-OSu

trans-N-Succinimidyl 4-(maleimidomethyl)cyclohexane-1-carboxylate

Formula:                    C16H18N₂O₆
Molecular Weight:     334,33 g/mole

CAS:  64987-85-5

CODE:  MAA1000

1g:       EUR    300,-    US$   420,-
5g:       EUR  1200,-    US$ 1680,-

Prices are in EUR, net, exw Germany, shipping not include

Troc-OSu

Reported applications:

Introduction of 9-fluorenylmethyloxycarbonyl, trichloroethoxycarbonyl, and benzyloxycarbonyl amine protecting groups into O-unprotected hydroxylamino acids using succinimidyl carbonates; Anelka Paquet; Can. J. Chem.; 1982; 60: 976.

Widely Applicable Deprotection Method of 2,2,2-Trichloroethoxycarbonyl (Troc) Group Using Tetrabutylammonium Fluoride; Cheng-yuan Huanga; Ning Wanga; Katsumasa Fujikia; Yuji Otsukaa; Masao Akamatsua; Yukari Fujimotoa; Koichi Fukasea; Journal of Carbohydrate Chemistry 2010; 29(6): 289 – 298.

Actiplus-CALB

Lipase B from Candida antarctica (EC 3.1.1.3)
adsorbed on hydrophobic polymer Polystyrene DVB cross linked, 300-700µm,
Synthetic Activity >10.000 U/g (dry), 
very high mechanical stability - suitable for packed bed reactors

Green Advantages of using Phacm for Cystein Protection

PGA (Penicillin G Amidase, Penicillin Acylase, Penicillin Amidohydrolase from E.coli on acrylic resin, Systematic name: Penicillin amidohydrolase, E.C. 3.5.1.11) has an active pocket, which is very specific for phenyl acetic acid. The prominent commercial use is hydrolysis of a phenylacetamid bond during production of the penicillin API 6-APA (De Martin et al., J. Mol. Catal. B:Enzymatic 1999; 6: 437). The high specifity of PGA towards the Phenylacetyl moiety makes the use of Phacm as new alternative for Acm very promising. The principle use already was discovered by Albericio et al in 1995 using native PGA. Today PGA is available as immobilized preparation, so by simple filtration process PGA can be removed from the reaction mixture and reused many times.

Dendron Building Blocks for Click Chemistry

Dendrimers offer a new possibility to derivatize small molecules, surfaces or biopharmaceuticals with a monodisperse macromolecule and alter in this way properties like solubility and hydrophilicity. Immunogenicity and pharmacokinetics of pharmaceuticals will be improved. The synthetic approach for designing these dendrons of different generations is based on 2,2-bis(hydroxymethyl) propionic acid, which is a non-toxic and biocompatible building block.

The size can be designed from 250 g/mole for 1st generation dendrons to over 4400 g/mole with 5th generation compounds. Dendrimers can be designed reaching even a molecular weight of some 10.000 Da. As focal point alkyne and azido functions are used with appropriate counter parts in any type of click chemistry reaction. Olefinic functions offer the possibility for addition reaction or conjugation by metathesis reactions or photo reactions with the aid of UV light. For the modification of Gold surfaces sulphur bearing dendrons can be used, they also conjugate with biologicals via disulfide bridge formation.

Parallel Synthesis and Reaction Optimization

Understanding enzyme immobilisation

The concept of internal solubilization in peptide synthesis: ethylene glycol-based protecting groups

A novel, ethylene glycol-based protecting group is designed and synthesized for use in solid phase peptide synthesis.