Blog - Amino Acids

  1. UAA! Discover Aminocoumarinyl Lysine

    We say "UAA"! By genetic code expansion you can incorporate our novel aminocoumarinyl lysine in your favorite protein where it serves you as fluorescent probe or photo-activatable caged lysine.

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  2. Discover TIQ and TIC as Proline Analogs

    Implement our 1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid (TIQ) and -3-carboxylic acid (TIC) building blocks as proline analogs! Shape your peptide and improve binding and performance!

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  3. The Photosensitive MNI Protecting Group

    Shining light on 4-methoxy-7-nitroindoline (MNI) photocaged aspartate and glutamate building blocks suitable for Fmoc-SPPS. Liberate the sidechain carboxylic acid by irradiation with UV-light of 365 nm.

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  4. New Maillard Products for Peptide Synthesis and Analytics

    Benefit of our latest Maillard Reaction Product additions! Use them as reference standard for quality control and food analysis or synthesize modified peptides for research studies.

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  5. PotM: Furan-Crosslinking and 5HP2O as Maleimide Alternative

    Game Changer for Protein Modification: Discover oxidation-induced furan crosslinking and 5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2Os) as stable alternative to maleimides.

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  6. Chain Extension: Discover Homo Amino Acids

    We expanded our portfolio of Fmoc-protected homo amino acids. Benefit of their unique properties to modulate the stability, hydrophobicity, and biological performance of your peptide!

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  7. Hidden Champion – The Tetrahydropyranyl Protective Group

    Tetrahydropyranyl (THP) is an excellent protective group for hydroxy and thiol moieties but rarely used in solid-phase peptide synthesis (SPPS). Discover its advantages, e.g., over O/StBu and Trt.

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  8. Common Side Reactions in Fmoc Solid-Phase Peptide Synthesis

    Collect information about the most common side reactions during Fmoc SPPS and how to avoid them! Choose your building blocks and conditions wisely to avoid unnecessary trouble!

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  9. Bioisosteric Argininine Analogs

    Same but different! Expand your possibilities for peptide modification and fine-tuning by implementing Nω-carbamoylated arginine building blocks as bioisosteric arginine analogs.

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  10. Protecting Groups in SPPS

    Mix & Match. Discover typically employed protecting groups used to temporarily mask reactive functional moieties during solid-phase peptide synthesis to prevent undesired side-reactions.

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