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Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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Custom Synthesis of Click-able compounds for Cu-free Click Conjugation
The presence of catalytic copper, limits the in vivo application of the Click this reaction for several reasons.
We offer custom synthesis of Strained Cyclooctynes and Substituted 1,2,4,5- Tetrazines as building blocks for fast Click reactions in the absence of any catalyst.
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Custom Synthesis of beta & gamma Amino Acids including Statine Analogues
GABA is a neurotransmitter in the central nervous system of mammals and its deficiency is associated with severe neurological disorders. Statine, a GABA analogue, occurs in several peptide APIs.
Derivatives of gamma-amino acid analogues are of continued vital interest for a variety of applications in medicinal chemistry.
We have a tool box available to offer a broad range of substituted gamma-amino acids and statines on custom synthesis basis.
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Preloaded Resins for Synthesis of Peptide Amides
Used for Efficient and Economic Bulk Synthesis of Peptide APIs:
A new technology is available with a set of new preloaded resins, which enable the synthesis of peptide amides WITHOUT ANY LINKER.
Amino acid amides, which bear a functional side chain, are immobilized on acid sensitive resins. This makes process development, small scale synthesis, bulk production and in-process control very easy.Find more technical details in our application for demonstration purposes with BIVALIRUDIN.
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Benzotriazole Amino Acids
Benzotriazol activated carboxylic acids:
- Fast reaction (within minutes) at room temperature with amines and other nucleophiles under addition of base (in both water and non- aqueous solvents).
- Stable to racemization when coupling with nucleophiles.
- High solubility in organic solvents like DMF and DCM.
- Stable in water.
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Luciferin for Research and Industry – from MG to KG Scale
In modern biotechnology there are numerous applications for the luminogenic luciferase assay. We supply luciferin from mg scale for research applications like monitoring of gene expression or tumor growth up to kg quantities for hygiene surveillance in food industry
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New: dPEG-Phospholipids for superior liposomes
Novel liposomes built of dPEG-Phospholipids with defined PEG chain length provide prolonged blood-circulation time and improved cellular uptake as administration carriers for drugs, delivering active molecules to the desired target.
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Bis-Boc-guanidinopyrazole
Arginine rich peptides show increased interest during the last years as they have the capability to cross cell and blood brain barrier membranes.
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Aspartic and Glutamic Acid Homologues
Arginine rich peptides show increased interest during the last years as the have the capability to cross cell and blood brain barrier membranes.
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New Click Linker
Click chemistry has developed to a widely used conjugation technique. Here are our latest developments of new short linker for hydrophilic and hydrophobic applications.
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Thio-Prolines - Rigid Homo-Cys Analogues
Cysteins and homocysteins are found in many natural and artificial peptide sequences. Mercaptoproline is a rigid analogue of homocysteine offering several options to the medicinal chemist.
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