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Visit this regularly updated section to check out the latest additions to our portfolio, as well as the latest developments at Iris Biotech.
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Photocleavable Cys Protecting Group
This oNv (2-Nitroveratryl) is the latest addition to our repertoire of cysteine protecting groups. It opens new possibilities of orthogonality to the existing strategies for disulfide bridge formation.
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Copper-Free Click Conjugation
Many efforts have been undertaken to develop possibilities for copper-free Diels-Alder reaction based conjugation. Very promising options are Tetrazines and appropriate Dienophiles, as they are patent free and have potential for affordable bulk application.
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Stable Conjugation with Thiols
Maleimide (MAL) reacts rather specific with free thiol groups and forms appropriate conjugates. However, this reaction is slightly reversible, resulting in loss of the conjugation partner.
Amino functions open the maleimido ring structure through hydrolysis with nucleophilc neighboring effect and thus inhibit the undesired release reaction.
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Structural Element: Aminoisobutyric Acid and Homologues
Aminoisobutyric acid (Aib) and its homologues are a strong helix promoters in peptide mimetics. Aib-containing model peptides are already used in cancer treatment, antimicrobial peptides and cell penetrating peptides (CPP).
We offer Aib and its homologues positioning the dimethyl fragment either close to the N- or to the C-terminus.
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Synthesis of Protected Peptide Amide Fragments with Sieber Resin
Fmoc-Sieber amide resin is an acid-labile carrier for solid phase synthesis of peptide amides. Cleavage with only 1% TFA makes it an ideal carrier for the synthesis of protected peptide fragments in fragment condensation strategies for the synthesis of long peptides.
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Amino-PEG-Acids for Increased Solubilization.
For introducing amino-PEG-acids into a peptide chain, several affordable building blocks are available with all conventional protecting groups. They can be incorporated at any sequence position by standard coupling protocols.
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Custom Synthesis of Clicky Acids - Fatty Acids for Click Conjugation
Fatty Acids for Click Conjugation
Fatty acid residues and alkyl chains in general can improve solubility and anchoring in membranes and other Lipophilie environments.
Find a selection of promptly available short and long chain clickable acids in our web store. Any other – including functional groups for copper-free Click conjugation can be made on custom synthesis basis.
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Polar Amino Acids for Increased Solubilization
alpha-Sulfo-beta-Alanine has been used to couple to hydrophobic molecules and peptides and increase solubility. Attachment can be carried out by conventional Fmoc/tBu protocols.
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The NEW Iris Biotech Catalogue is available now!
In the era of internet a printed edition of a catalogue still has some advantages and fans.
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You can make handwritten notes in your catalogue. The overview at each page inspires you to think about structure diversity or alternative strategies in terms of protecting groups, coupling reagents or immobilization. You quickly see what is commercially available and get fast an impression about approximate costs of your synthesis. -
Custom Synthesis of Alkyne Amino Acids Analogues for Click Conjugation
1,4-substituted 1,2,3-triazole are isosteric to peptide bonds and result in peptide mimetics which even retain activity e.g. in case of certain tyrosinease inhibitors.
We offer custom synthesis of Alkyne Amino Acid Analogues as building blocks for triazol formation via Click conjugation. Side chains can represent all natural amino acids or unusual residues. In combination with our alpha-azido acids we can offer the whole range of building blocks to design Click-peptide bond analogues for every proteinogenic amino acid.
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