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Fmoc-Dbz(o-Boc)-OH
Nombre químico: 3-(Fmoc-amino)-4-(Boc-amino)-benzoic acid // Sinónimos: 4-tert-Butoxycarbonylamino-3-(9H-fluoren-9-ylmethoxycarbonylamino)-benzoic acid, 3-Fmoc-4-Boc-diaminobenzoic acid
- Nº Artículo:FAA3167
- Nº CAS:1823479-63-5
- Fórmula:C27H26N2O6
- Storage temperature:-20°C
- Masa molecular:474,51 g/mol
from 300,00 €
description
Typically, 3,4-diaminobenzoid acid (Dbz) is used for the efficient synthesis of peptide thioesters by Fmoc chemistry solid phase peptide synthesis. Optionally, a solubility tag can be attached to the C-terminus. Protection of the free amine is required to prevent over-acylation observed using the typical Dawson reagent. In addition, Boc-protection of the ortho-amine prevents formation of undesired side-products, e.g. benzimidazolinone formation, which might be observed for other types of protecting groups.
references
Benzimidazolinone-Free Peptide o-Aminoanilides for Chemical Protein Synthesis; J. Mannuthodikayil, S. Singh, A. Biswas, A. Kar, W. Tabassum, P. Vydyam, M. K. Bhattacharyya, and K. Mandal; Org. Lett. 2019; 21: 9040-9044. https://doi.org/10.1021/acs.orglett.9b03440.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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