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Fmoc-trans-Ac6c(4-Boc-NH)-OH
Nombre químico: (1r,4r)-1-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid
- Nº Artículo:FAA8635
- Nº CAS:2188242-20-6
- Fórmula:C27H32N2O6
- Storage temperature:2-8°C
- Masa molecular:480,56 g/mol
from 1.500,00 €
description
This derivative can be used as constrained building block for structure activity relationship studies. Such alpha,alpha-disubstituted amino acids are widely used in peptide design because of their structure promoting effects.
references
Synthesis of six-membered carboyclic ring alpha,alpha-disubstituted amino acids and arginine-rich peptides to investigate the effect of ring size on the properties of the peptide; T. Kato, Y. Kita, K. Iwanari, A. Asano, M. Oba, M. Tanaka, M. Doi; Bioorg. Med. Chem. 2021; 38: 116111. https://doi.org/10.1016/j.bmc.2021.116111.
Synthesis of a series of polar, orthogonally protected, alpha,alpha-disubstituted amino acids; T. Scott Yokum, M. G. Bursavich, S. A. Piha-Paul, D. A. Hall, M. L. McLaughlin; Tetrahedron Lett. 1997; 38(23): 4013-4016. https://doi.org/10.1016/S0040-4039(97)00822-8.
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