Fmoc-L-Lys(MeDmb)-OH

Nombre químico: (2S)-6-{[1-(1,3-dimethyl-2,4,6-trioxo-1,3-diazinan-5-ylidene)ethyl]amino}-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)hexanoic acid // Sinónimos: N2-(((9H-fluoren-9-yl)methoxy)carbonyl)-N6-(1-(1,3-dimethyl-2,4,6-trioxotetrahydropyrimidin-5(2H)-ylidene)ethyl)-L-lysine, Fmoc-Lys(MeDmb)-OH

  • Nº Artículo:FAA8840
  • Fórmula:C29H32N4O7
  • Storage temperature:2-8°C
  • Masa molecular:548,60 g/mol
  • Pureza:min.98%
  • Pureza Enantiomérica:min.99,9%

from 84,00 €

Grouped product items
Cantidad Unidad de venta Precio Unidad de almacenamiento de stock (SKU) Disponibilidad
1 g
84,00 €
FAA8840.1000
<10 días laborables
5 g
300,00 €
FAA8840.5000
<10 días laborables
25 g
1.200,00 €
FAA8840.9025
peticón
description

Novel Lysine building-block for SPPS bearing a new side-chain protecting-group. MeDmb is an orthogonal protecting group, stable under acidic and basic conditions used during SPPS and can be cleaved by a mild solution of 2% hydrazine hydrate in DMF and 2% hydroxylamine in DMF. The advantage of MeDmb over dimedone derivatives is the increased hydrophilicity, which should increase their solubility in a broad range of solvents, including green solvents.


references

Scope and Limitations of Barbituric and Thiobarbituric Amino Acid Derivatives as Protecting Groups for Solid-Phase Peptide Synthesis: Towards a Green Protecting Group; S. Ramkisson, H. H. Al-Rasheed, K. A. Dahlous, B. G. De La Torre, A. El-Faham, F. Albericio; Chem. Select 2021; 6(26): 6626-6630. https://doi.org/10.1002/slct.202101539


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