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H-L-Lys(2-N3-Z)-OH
Nombre químico: N6-(((2-azidobenzyl)oxy)carbonyl)-L-lysine // Sinónimos: H-Lys(2-N3-Z), H-Lys(Z(2-N3))-OH, o-Az-Z-Lys, oAzZLys, H-Lys(Z-2-N3)-OH, N-epsilon-o-azidobenzyloxycarbonyl lysine, N-epsilon-(o-azidobenzyloxycarbonyl)-L-lysine, OABK, (2S)-6-(2-Azido-benzyloxycarbonylamino)-2-amino-hexanoic acid
- Nº Artículo:HAA9380
- Nº CAS:1131963-69-3
- Fórmula:C14H19N5O4
- Storage temperature:2-8°C
- Masa molecular:321,34 g/mol
- Pureza:min.98%
- Pureza Enantiomérica:min.99,7%
from 132,00 €
description
Modified Lysine containing an Azide moiety as a bioorthogonal ligation handle. This Lysine derivative can be incorporated into proteins for further modification using Click-chemistry or Staudinger ligation (Lysine decaging).
references
Multistep Engineering of Pyrrolysyl-tRNA Synthetase to Genetically Encode N-epsilon-(o-Azidobenzyloxycarbonyl) lysine for Site-Specific Protein Modification; T. Yanagisawa, R. Ishii, R. Fukunaga, T. Kobayashi, K. Sakamoto, S. Yokoyama; Chem. Biol. 2008, 15: 1187–1197. https://doi.org/10.1016/j.chembiol.2008.10.004
Genetic-code evolution for protein synthesis with non-natural amino acids; T. Mukai, T. Yanagisawa, K. Ohtake, M. Wakamori, J. Adachi, N. Hino, A. Sato, T. Kobayashi, A. Hayashi, M. Shirouzu, T. Umehara, S. Yokoyama, K. Sakamoto; Biochem. Biophys. Res. Commun. 2011, 411(4): 757-61. https://doi.org/10.1016/j.bbrc.2011.07.020
Genetic Code Expansion in Zebrafish Embryos and Its Application to Optical Control of Cell Signaling; J. Liu, J. Hemphill, S. Samanta, M. Tsang, A. Deiters; J. Am. Chem. Soc. 2017, 139(27): 9100–9103. https://doi.org/10.1021/jacs.7b02145
Extensive Survey of Antibody Invariant Positions for Efficient Chemical Conjugation Using Expanded Genetic Codes; A. Kato, M. Kuratani, T. Yanagisawa, K. Ohtake, A. Hayashi, Y. Amano, K. Kimura, S. Yokoyama, K. Sakamoto, Y. Shiraishi; Bioconjugate Chem. 2017, 28(8): 2099–2108. https://doi.org/10.1021/acs.bioconjchem.7b00265
Small-molecule control of protein function through Staudinger reduction; J. Luo, Q. Liu, K. Morihiro, A. Deiters; Nat. Chem. 2016, (8): 1027–1034. https://doi.org/10.1038/nchem.2573
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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