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Thank you very much for your interest in our products. All prices listed on our website are ex-works, Germany, and may attract customs duties when imported.
You may/will be contacted by the shipping company for additional documentation that may be required by the US Customs for clearance.
We offer you the convenience of buying through a local partner, Peptide Solutions LLC who can import the shipment as well as prepay the customs duties and brokerage on your behalf and provide the convenience of a domestic sale.
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A new attempt to cure diseases caused by excessive expression of a certain protein is targeted degradation via the cell’s ubiquitin–proteosome system by using proteolysis targeting chimeras (PROTACs*). PROTACs consist of two linked protein ligands: one with high affinity for E3 ubiquitin ligase and one with high affinity for the protein of interest (POI). To construct a suitable PROTAC, we here offer a variety of E3 ubiquitin ligase ligands and their combination with linkers of various length and elective amino-, carboxyl-, mercapto- or click-reactive end (“Partial PROTACs”). Further to these pre-designed building blocks, we are happy to synthesize for you many other ligand-linker combinations or “complete PROTACs” on custom synthesis basis.
* PROTAC is a registered trademark of Arvinas Operations, Inc. and is used under license.
