Name: MeTz-PEG(4)-NH2*HCl
SKU: RL-2370
Availability: InStock

Grouped product items

Cantidad

Unidad de venta

Precio

Unidad de almacenamiento de stock (SKU)

25 mg

220,00 €

RL-2370.0025

100 mg

510,00 €

RL-2370.0100

500 mg

1.510,00 €

RL-2370.0500

1 g

2.270,00 €

RL-2370.1000

description

New three-functional clickable cross-linker, which shows superior thermal stability compared to DIBAC and other cyclooctyne based ring systems. DACN also shows high specifity and does not undergo side reactions with thiols (eg. from cysteines) as it has been observed with cyclooctyne derivatives and other constrained ring systems.

references

2‑Aminobenzenesulfonamide-Containing Cyclononyne as Adjustable Click Reagent for Strain-Promoted Azide−Alkyne Cycloaddition; Kyosuke Kaneda, Risa Naruse, and Syota Yamamoto; Org. Lett. 2017; 19(5): 1096–1099. DOI: 10.1021/acs.orglett.7b00123

Heteroatom-embedded Medium-Sized Cycloalkynes: Concise Synthesis, Structural Analysis, and Reactions; Runyan Ni, Naoto Mitsuda, Takeru Kashiwagi, Kazunobu Igawa, and Katsuhiko Tomooka; Angew. Chem. Int. Ed. 2015; 54: 1190-1194. DOI: 10.1002/anie.201409910.

A Strain-Promoted [3 + 2] Azide-Alkyne Cycloaddition for Covalent Modification of Biomolecules in Living Systems; Nicholas J. Agard, Jennifer A. Prescher, and Carolyn R. Bertozzi; J. Am. Chem. Soc. 2004; 126: 15046-15047. DOI: 10.1021/ja044996f.

Second-Generation Difluorinated Cyclooctynes for Copper-Free Click Chemistry; Julian A. Codelli, Jeremy M. Baskin, Nicholas J. Agard, and

Carolyn R. Bertozzi; J. Am. Chem. Soc. 2008; 130: 11486–11493; DOI: 10.1021/ja803086r.

Aza-dibenzocyclooctynes for fast and efficient enzyme PEGylation via copper-free (3+2) cycloaddition; Marjoke F. Debets, Sander S. van Berkel, Sanne Schoffelen, Floris P. J. T. Rutjes, Jan C. M. van Hest and Floris L. van Delft; Chem. Commun. 2010; 46: 97. DOI: 10.1039/b917797c

Preventing Thiol-Yne Addition Improves the Specificity of Strain-Promoted Azide−Alkyne Cycloaddition; Remon van Geel, Ger J. M. Pruijn, Floris L. van Delft, and Wilbert C. Boelens; Bioconjugate Chem. 2012; 23: 392. dx.doi.org/10.1021/bc200365k.