Name: Photo-Butylamine
SKU: RL-2910
Availability: InStock

Grouped product items

Cantidad

Unidad de venta

Precio

Unidad de almacenamiento de stock (SKU)

Disponibilidad

250 mg

350,00 €

RL-2910.0250

500 mg

600,00 €

RL-2910.0500

1 g

1.000,00 €

RL-2910.0001

description

Nucleophilic photo cross-linker. The amine function can conjugate to electrophiles like carbonyl functions with standard reaction conditions. The diazirine ring will dismiss N2 under illumination of UV light and the remaining carbene will undergo insertion and addition reaction to any neighboring molecule and irreversibly form a covalent bond.

references

Cross-linking chemistry and biology: development of multifunctional photoaffinity probes. Takenori Tomohiro, Makoto Hashimoto, Yasumaru Hatanaka; Chem. Record 2005; 5(6): 385-395. DOI: 10.1002/tcr.20058

Recent Progress in Diazirine-Based Photoaffinity Labeling. Makoto Hashimoto, Yasumaru Hatanaka; Eur. J. Org. Chem. 2008; 2513-2523. DOI: 10.1002/ejoc.200701069

Endeavors to Make the Photophore, Diazirine Easy to Use. Yutaka Sadakane; Yakugaku Zasshi 2007; 127(10): 1693-1699. DOI: org/10.1248/yakushi.127.1693

Fishing for Drug Targets: A Focus on Diazirine Photoaffinity Probe Synthesis. James R. Hill, Avril A. B. Robertson; J. Med. Chem. 2018; 61: 6945−6963. DOI: 10.1021/acs.jmedchem.7b01561.

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