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Nombre químico: 3-(2-(2-(9-Fluorenylmethyl)oxycarbonylaminoethoxy)ethoxy)-1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-propan-1-ol // Sinónimos: Fmoc-Ddae-OH, (9H-fluoren-9-yl)methyl N-(2-{2-[3-(4,4-dimethyl- 2,6-dioxocyclohexylidene)-3-hydroxypropoxy]ethoxy}ethyl)carbamate
from 100,00 €
Fmoc-Ddae-OH is used as a solubility-enhancing linker in the “helping hand” strategy for purification of highly insoluble peptides. Several Lysine residues are attached to this linker using Fmoc-SPPS. The solubilizing tag can be removed with 1M hydrazine or hydroxylamine solution. For further modification and commercial use please refer to the claims in patent WO 2011058188 (A1).
A Helping Hand to Overcome Solubility Challenges in Chemical Protein Synthesis; M. T. Jacobsen, M. E. Petersen, X. Ye, M. Galibert, G. H. Lorimer, V. Aucagne and M. S. Kay; J Am Chem Soc 2016; 138: 11775-82. https://doi.org/10.1021/jacs.6b05719
Synthesis of hydrophobic insulin-based peptides using a helping hand strategy; M. M. Disotuar, M. E. Petersen, J. M. Nogueira, M. S. Kay and D. H. Chou; Org Biomol Chem 2019; 17: 1703-1708. https://doi.org/10.1039/c8ob01212a
Compounds and methods for purifying peptides produced by solid phase peptide synthesis; V. Aucagne, A. Delmas; 2011; WO2011058188A1; CNRS; U.S. Patent No. 9,073,969, 2015.
