Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contact rapide
Veuillez m'envoyer plus d'informations sur
Boc-beta,beta-diMe-L-Ser-OH
Nom chimique: N-alpha-t-Butyloxycarbonyl-beta,beta-dimethyl-L-serine // Synonymes: Boc-L-Hvl-OH, (S)-Boc-beta-hydroxy-valine, (S)-Boc-2-amino-3-hydroxy-3-methyl-butyric acid, (S)-Boc-beta,beta-dimethyl-serine,(S)-2-(tert-butoxycarbonylamino)-3-hydroxy-3-methylbutanoic acid, Boc-be ta,beta-diMe-Ser-OH
- n° Art.:BAA2840
- n° CAS:102507-13-1
- Formule:C10H19NO5
- Storage temperature:2-8°C
- Masse moléculaire:233,26 g/mol
from 100,00 €
description
beta,beta-Dimethylation of amino acids stabilizes appropriate peptides towards digestion by proteases. The hydroxyl function of this serine building block is unprotected, because acylation does not happen to tertiary alcohols during standard Boc/Bzl coupling protocols.
references
A General Method for Making Peptide Therapeutics Resistant to Serine Protease Degradation: Application to Dipeptidyl Peptidase IV Substrates; Kathryn R. Heard, Wengen Wu, Youhua Li, Peng Zhao, Iwona Woznica, Jack H. Lai, Martin Beinborn, David G. Sanford, Matthew T. Dimare, Amrita K. Chiluwal, Diane E. Peters, Danielle Whicher, James L. Sudmeier, and William W. Bachovchin; J. Med. Chem. 2013; 56: 8339−8351. dx.doi.org/10.1021/jm400423p.
Total synthesis of the large non-ribosomal peptide polytheonamide B; Masayuki Inoue, Naoki Shinohara, Shintaro Tanabe, Tomoaki Takahashi, Ken Okura, Hiroaki Itoh, Yuki Mizoguchi, Maiko Iida, Nayoung Lee and Shigeru Matsuoka; Nature Chem. 2010; 2: 281-285. DOI: 10.1038/nchem.554.
Besoin d'informations supplémentaires sur ce produit?
entrer en contact
Des produits qui pourraient également vous intéresser!
