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Ramage Resin
Nom chimique: 2-(5-(9-Fluorenylmethyloxycarbonyl)amino-10,11-dihydro-5H-dibenzo[a,d]cycloheptenyl-2-oxy)actamido polystyrene // Synonymes: DCHD Resin, Ramage Amide AM Resin
- n° Art.:BR-5204
- Storage temperature:2-8°C
- Taille des particules:100-200 mesh
- DVB réticulation:1% DVB
- Chargement:0.3-1.5 mmol/g
from 170,00 €
description
Alternative to the commonly used Rink-resin. The three-circular structure of the Ramage linker prevents fragmentation of the linker during cleavage from the resin followed by back alkylation. A common phenomenon observed during peptide synthesis with the open structure of the Rink-amide linker. Hence, Ramage linker delivers peptides with higher purity and less impurities, than peptides produced with the Rink-amide linker. Ramage resin is particularly recommended for C-terminal Phe, Tyr and Ile. Following Fmoc removal, the resin can be acylated under standard conditions with Fmoc/tBu protocols. Peptide amides can be released from the resin with 50% TFA in DCM or 95% aqueous TFA.
references
Potassium channel modulation by a toxin domain in matrix metalloprotease 23; S. Rangaraju, K. K. Khoo, Z. P. Feng, G. Crossley, D. Nugent, I. Khaytin, V. Chi, C. Pham, P. Calabresi, M. W. Pennington, R. S. Norton and K. G. Chandy; J Biol Chem 2010; 285: 9124-36. https://doi.org/10.1074/jbc.M109.071266
An immunomodulator used to protect young in the pouch of the Tammar wallaby, Macropus eugenii; R. V. Baudinette, P. Boontheung, I. F. Musgrave, P. A. Wabnitz, V. M. Maselli, J. Skinner, P. F. Alewood, C. S. Brinkworth and J. H. Bowie; FEBS J 2005; 272: 433-43. https://doi.org/10.1111/j.1742-4658.2004.04483.x
Evaluation of some fluorogenic substrates for continuous assay of aminopeptidase P; S. J. Hawthorne, P. Harriott, J. Lim, A. J. Turner, B. Walker and C. H. Williams; Anal Biochem 1997; 253: 13-7. https://doi.org/10.1006/abio.1997.2320
Design of a versatile linker for solid phase peptide synthesis: Synthesis of C-terminal primary/seconary amides and hydrazides; R. Ramage, S. L. Irving and C. McInnes; Tetrahedron Letters 1993; 34: 6599-6602. https://doi.org/10.1016/0040-4039(93)88115-y
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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