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Fmoc-L-Arg(Me,Pbf)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N'-methyl-N''-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine // Synonymes: Fmoc-Arg(Me)(Pbf)-OH, Fmoc-N-omega-methyl-L-arginine(Pbf), Fmoc-Arg(Me,Pbf)-OH
- n° Art.:FAA3360
- n° CAS:1135616-49-7
- Formule:C35H42N4O7S
- Storage temperature:2-8°C
- Masse moléculaire:662,8 g/mol
from 150,00 €
description
Arg(Me) can be introduced in peptide sequences by conventional Fmoc/tBu SPPS using this derivative. N-omega-Methylation is a widespread post-translational modification of Arg-containing proteins.
references
Rational Design and Synthesis of Modified Teixobactin Analogues: In Vitro Antibacterial Activity against Staphylococcus aureus, Propionibacterium acnes and Pseudomonas aeruginosa; V. Ng, S. A. Kuehne and W. C. Chan; Chemistry 2018; 24: 9136-9147. doi: https://doi.org/10.1002/chem.201801423
Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction; H. Karatas, Y. Li, L. Liu, J. Ji, S. Lee, Y. Chen, J. Yang, L. Huang, D. Bernard, J. Xu, E. C. Townsend, F. Cao, X. Ran, X. Li, B. Wen, D. Sun, J. A. Stuckey, M. Lei, Y. Dou and S. Wang; Journal of medicinal chemistry 2017; 60: 4818-4839. doi: https://doi.org/10.1021/acs.jmedchem.6b01796
Iterative conversion of cyclin binding groove peptides into druglike CDK inhibitors with antitumor activity; P. N. Premnath, S. N. Craig, S. Liu, E. L. Anderson, A. I. Grigoroudis, G. Kontopidis, T. L. Perkins, M. D. Wyatt, D. L. Pittman and C. McInnes; Journal of medicinal chemistry 2015; 58: 433-42. doi: https://doi.org/10.1021/jm5015023
Effect of arginine methylation on the RNA recognition and cellular uptake of Tat-derived peptides; J. H. Li, W. C. Chiu, Y. C. Yao and R. P. Cheng; Bioorg Med Chem 2015; 23: 2281-6. doi: https://doi.org/10.1016/j.bmc.2015.01.051
Trypsin resistance of a decapeptide KISS1R agonist containing an Nomega-methylarginine substitution; T. Asami, N. Nishizawa, Y. Ishibashi, K. Nishibori, Y. Horikoshi, H. Matsumoto, T. Ohtaki and C. Kitada; Bioorg Med Chem Lett 2012; 22: 6328-32. doi: https://doi.org/10.1016/j.bmcl.2012.08.087
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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