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Fmoc-L-Cys(oNv)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-S-(2-nitroveratryl)-L-cysteine // Synonymes: (R)-2-(((9H-fluoren-9-yl)methoxy)carbonylamino)-3-(4,5-dimethoxy-2-nitrobenzylthio)propanoic acid, Fmoc-Cys(oNv)-OH
- n° Art.:FAA3970
- n° CAS:214633-71-3
- Formule:C27H26N2O8S
- Storage temperature:2-8°C
- Masse moléculaire:538,57 g/mol
from 475,00 €
description
2-nitroveratryl (oNv) is a new orthogonal group which is compatible with SPPS protocols and that can be cleaved by photolysis (350 nm) under ambient conditions. In combination with complementary S-pyridinesulfenyl activation, disulfide bonds are formed rapidly in situ. In order to demonstrate the versatility of this approach, it was applied to the synthesis of a number of model peptides: oxytocin, alpha-conotoxin ImI, and human insulin.
references
Karas J.A., Scanlon D.B., Forbes B.E., Vetter I., Lewis R.J., Gardiner J., Separovic F., Wade J.D., Hossain M.A.; 2-Nitroveratryl as a Photocleavable Thiol-Protecting Group for Directed Disulfide Bond Formation in the Chemical Synthesis of Insulin; Chem. Eur. J. 2014; 20: 9549-9552. DOI: 10.1002/chem.201403574.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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