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Fmoc-L-Trp(7-Cl)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-7-chloro-L-tryptophan // Synonymes: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(7-chloro-1H-indol-3-yl)propanoic acid, 7-chloro-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-tryptophan, Fmoc-7-chloro-L-tryptophan,Fmoc-Trp(7-Cl)-OH
- n° Art.:FAA8475
- n° CAS:2382374-53-8
- Formule:C26H21ClN2O4
- Storage temperature:-20°C
- Masse moléculaire:460,91 g/mol
from 760,00 €
description
FAA8475 is a Fmoc protected chloro derivative of L-Tryptophan. Tryptophan is a key residue in many important natural products, e.g. the antibiotic daptomycin. The use of synthetic derivatives of natural amino acids allows to approach a broad variety of molecules enabling the study of structure-activity relationships. Especially the 7-halotryptophan motif is also found in many biologically active natural products.
references
Dynamic Kinetic Resolution for Asymmetric Synthesis of L-Noncanonical Amino Acids from D-Ser Using Tryptophan Synthase and Alanine Racemase; J. Yu, J. Li, X. Gao, S. Zeng, H. Zhang, J. Liu, Q. Jiao; Eur. J. Org. Chem. 2019; 6618-6625. https://doi.org/10.1002/ejoc.201901132
Buchwald Hartwig diversification of unprotected halotryptophans, halotryptophan containing tripeptides and the natural product barettin in aqueous conditions; Y. J. G. Renault, R. Lynch, E. Marelli, S. V. Sharma, C. Pubill-Ulldemolins, J. A. Sharp, C. Cartmell, P. Cárdenas, R. J. M. Goss; Chem. Commun. 2019; 55: 13653-13656. https://doi.org/10.1039/c9cc02554e.
The first one-pot synthesis of L-7-Iodotryptophan from 7-Iodoindole and Serine, and an improved synthesis of other L-7-Halotryptophans; D. R. M. Smith, T. Willemse, D. S. Gkotsi, W. Schepens, B. U. W. Maes, S. Ballet, R. J. M. Goss; Org. Lett. 2014; 16: 2622-2625. https://doi.org/10.1021/ol5007746.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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