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Fmoc-L-Tyr(SO3DCV)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-O-(dichlorovinyl-sulfo)-L-tyrosine // Synonymes: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((((2,2-dichlorovinyl)oxy)sulfonyl)oxy)phenyl)propanoic acid, Fmoc-Tyr(SO3DCV)-OH,O-[[(2,2-dichloroethenyl)oxy]sulfonyl]-N-[(9H-fluoren-9-ylmet hoxy)carbonyl]-L-Tyrosine
- n° Art.:FAA8485
- n° CAS:1151854-06-6
- Formule:C26H21Cl2NO8S
- Storage temperature:2-8°C
- Masse moléculaire:578,41 g/mol
- Pureté:min. 98%
from 430,00 €
description
A derivative for the synthesis of sulfotyrosine-containing peptides by Fmoc-SPPS. Tyrosine sulfation is a post translational modification that occurs on integral membrane and secreted proteins, and plays a crucial role in mediating biological processes. Thus, this derivative is useful for the study of site-specific tyrosine sulfation and its effect on peptide stability and activity. The sulfate group of FAA8485 is protected with a dichlorovinyl (DCV) group. After synthesis, the peptide is cleaved from the resin using TFA/TIS and all side chain protective groups except DCV are removed. The DCV group is removed at the end of the synthesis by hydrogenolysis using Pd/C, H2 and ammonium formate.
references
Synthesis of disulfated peptides corresponding to the N-terminus of chemokines receptors CXCR6 (CXCR6 1-20) and DARC (DARC 8-42) using a sulfate-protecting group strategy; A. M. Ali, S. D. Taylor; J. Pept. Sci. 2010; 16(4): 190-199. https://doi.org/10.1002/psc.1220.
Efficient solid-phase synthesis of sulfotyrosine peptides using a sulfate protecting-group strategy; A. M. Ali, S. D. Taylor; Angew. Chem. Int. Ed. Engl. 2009; 48(11): 2024-6. https://doi.org/10.1002/anie.200805642.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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