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Fmoc-L-Chg(3-Me)-OH
Nom chimique: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-methyl-cyclohexylglycine // Synonymes: (S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-(1-methylcyclohexyl)acetic acid, (2S)-2-(Fmoc-amino)-2-(1-methylcyclohexyl)acetic acid, N-Fmoc-b-methyl cyclohexyl glycine,N-alpha-(9-Fluorenylmet hyloxycarbonyl)-2-(1-methylcyclohexyl)acetic acid,
- n° Art.:FAA8510
- n° CAS:2350460-04-5
- Formule:C24H27NO4
- Storage temperature:2-8°C
- Masse moléculaire:393,48 g/mol
from 900,00 €
description
This Fmoc-protected-b-methyl cyclohexyl glycine derivative can be used for structure-activity-relationship studies to optimize potency and the pharmacokinetic profile of drug candidates. Sidechain-derivatized amino acids have shown great potential in enhancing select properties of lead compounds. Besides the phenyl and bicyclo[1.1.1]pentane motif, cyclohexyl moieties may be employed to optimize binding of promising lead structures.
references
Scaleable catalytic asymmetric Strecker syntheses of unnatural alpha-amino acid; S. J. Zuend, M. P. Coughlin, M. P. Lalonde, E. N. Jacobsen; Nature 2009: 461(7266): 968-70. https://doi.org/10.1038/nature08484.
Novel potent inhibitors of hepatitis C virus (HCV) NS3 protease with cyclic sulfonyl P3 cappings; K. X. Chen, B. Vibulbhan, W. Yang, L. G. Nair, X. Tong, K.-C. Cheng, F. G. Njoroge; Bioorg. Med. Chem. Lett. 2009; 19(4): 1105-1109. https://doi.org/10.1016/j.bmcl.2008.12.111.
Second-Generation Highly Potent and Selective Inhibitors of the Hepatitis C Virus NS3 Serine Protease; K. X. Chen, L. Nair, B. Vibulbhan, W. Yang, A. Arasappan, S. L. Bogen, S. Venkatraman, F. Bennett, W. Pan, M. L. Blackman, A. I. Padilla, A. Prongay, K.-C. Cheng, X. Tong, N.-Y. Shih, F. G. Njoroge; J. Med. Chem. 2009; 52(5): 1370-1379. https://doi.org/10.1021/jm801238q.
Azepanone-based inhibitors of human cathepsin S: Optimization of selectivity via the P2 substituent; J. K. Kerns, H. Nie, W. Bondinell, K. L. Widdowson, D. S. Yamashita, A. Rahman, P. L. Podolin, D. C. Carpenter, Q. Jin, B. Riflade, X. Dong, N. Nevins, P. M. Keller, L. Mitchell. T. Tomaszek; Bioorg. Med. Chem. Lett. 2011; 21(15): 4409-4415. https://doi.org/10.1016/j.bmcl.2011.06.045.
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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