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N3-L-Cit-OH*DCHA
Nom chimique: (S)-2-Azido-citrulline dicyclohexylamine // Synonymes: N3-Cit*DCHA, N3-L-Cit-OH dicyclohexylamine salt, N3-Cit-OH, azido-citrulline dicyclohexylammonium salt, N-cyclohexylcyclohexanaminium (2S)-2-azido-5-(carbamoylamino)pentanoate,N3-Cit-OH*DCHA
- n° Art.:HAA4980
- n° CAS:1799421-66-1 net
- Formule:C6H11N5O3*C12H23N
- Storage temperature:2-8°C
- Masse moléculaire:201,18*181,32 g/mol
- Pureté:min. 98%
- Pureté Énantiomérique:min. 99,7%
from 90,00 €
description
Used by Genentech to construct novel peptidomimetic ADC linkers using Click-chemistry.
references
Discovery of Peptidomimetic Antibody–Drug Conjugate Linkers with Enhanced Protease Specificity. BinQing Wei, Janet Gunzner-Toste, Hui Yao, Tao Wang, Jing Wang, Zijin Xu, Jinhua Chen, John Wai, Jim Nonomiya, Siao Ping Tsai, Josefa Chuh, Katherine R. Kozak, Yichin Liu, Shang-Fan Yu, Jeff Lau, Guangmin Li, Gail D. Phillips, Doug Leipold, Amrita Kamath, Dian Su, Keyang Xu, Charles Eigenbrot, Stefan Steinbacher, Rachana Ohri, Helga Raab, Leanna R. Staben, Guiling Zhao, John A. Flygare, Thomas H. Pillow, Vishal Verma, Luke A. Masterson, Philip W. Howard, Brian Safina; J. Med. Chem. 2018; 61(3): 989-1000. DOI: 10.1021/acs.jmedchem.7b01430.
Peptidomimetic compounds and antibody-drug conjugates thereof. John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben, Philip Wilson Howard, Luke Masterson; PCT Int. Appl. 2015; WO 2015095124 A1.
Peptidomimetic compounds and antibody-drug conjugates thereof. Ho Huat Lee, Moana Tercel, John A. Flygare, Janet Gunzner-Toste, Thomas H. Pillow, Brian Safina, Leanna Staben, Vishal Verma, Binqing Wei, Guiling Zhao; PCT Int. Appl. 2015; WO 2015095227 A2.
Peptidomimetic compounds and antibody-drug conjugates thereof. John Flygare, Janet Gunzner-Toste, Thomas Pillow, Brian Safina, Vishal Verma, Binqing Wei, Guiling Zhao, Leanna Staben; PCT Int. Appl. 2015; WO 2015095223 A2.
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