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TT-232 triacetate
Nom chimique: H-D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2 (disulfide bridged) // Synonymes: CAP-232, TLN-232, TT232, TT 232
- n° Art.:LS-1520
- n° CAS:147159-51-1 (net)
- Formule:C45H58N10O9S2 (net)
- Storage temperature:-20°C
- Masse moléculaire:947,15 (net) g/mol
- Pureté:min. 98%
from 172,00 €
description
TT-232 is a structural analogue of somatostatin, a hormone with significant, selective antiproliferative, anti-inflammatory and antisecretory properties. In contrast to the parent hormone and its “traditional” analogues, this compound has strong and specific growth-inhibitory potential without the wide-ranging endocrine side-effects, including inhibition of insulin secretion provoking diabetes. Its mechanism of action is in line with the so-called signal-transduction therapy, where "internal communication" of cells is corrected without interfering with basic cell functions and machinery. Moreover, TT-232 acts on pyruvate kinase translocation and neurogenic inflammation. In vitro and in vivo studies show a selective antitumor activity with induction of strong apoptosis of cancer cells.
references
A tumor-selective somatostatin analog (TT-232) with strong in vitro and in vivo antitumor activity; G. Kéri, J. Érchegyi, A. Horváth, I. Mezõ, M. Idei, T. Vántus, A. Balogh, Z. Vadász, G. Bökönyi, J. Seprõdi, I. Teplán, O. Csuka, M. Tejeda, D. Gaál, Z. Szegedi, B. Szende, C. Roze, H. Kalthoff, A. Ullrich; Proc. Natl. Acad. Sci. U. S. A. 1996; 93: 12513-12518. https://doi.org/10.1073/pnas.93.22.12513.
Evaluation of the Antitumor Efficacy of the Somatostatin Structural Derivative TT-232 on Different Tumor Models; M. Tejeda, D. Gaál, L. Hullán, B. Hegymegi-Barakonyi, and G. Kéri; Anticancer Res. 2006; 26: 3477-83.
Inhibitory Effects of Synthetic Somatostatin Receptor Subtype 4 Agonists on Acute and Chronic Airway Inflammation and Hyperreactivity in the Mouse; K. Elekes, Z. Helyes, L. Kereskai, K. Sándor, E. Pintér, G. Pozsgai, V. Tékus, A. Bánvölgyi, J. Németh, T. Szûts, G. Kéri, J. Szolcsányi; Eur. J. Pharmacol. 2008; 578: 313-22. https://doi.org/10.1016/j.ejphar.2007.09.033.
Inhibitory Effect of Peptide Mimetics Including Naphthyl Group on DNA Polymerase Activity; A. Miyazaki, R. Ito, A. Enomoto, Y. Tsuda, I. Kuriyama, H. Yoshida, Y. Mizushina; Peptide Science 2013; 49: 201-202.
Somatostatin stimulates the migration of hepatic oval cells in the injured rat liver; Y. Jung, S.-H. Oh, R. P. Witek, B. E. Petersen; Liver Int. 2011; 32: 312-320. https://doi.org/10.1111/j.1478-3231.2011.02642.x
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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