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Used as a hydrophobic bioconjugation linker that can be further modified at the azido-position using Staudinger ligation or Click-chemistry. A substrate of lipoic acid ligase for labeling.
Redirecting lipoic acid ligase for cell surface protein labeling with small-molecule probes; Marta Fernández-Suárez, Hemanta Baruah, Laura Martínez-Hernández, Kathleen T Xie, Jeremy M Baskin, Carolyn R Bertozzi & Alice Y Ting; Nature Biotechnology 2007; 25: 1483–1487. DOI:10.1038/nbt1355.
N-Myristoyl transferase-mediated protein labelling in vivo; William P. Heal, Sasala R. Wickramasinghe, Robin J. Leatherbarrow and Edward W. Tate; Org. Biomol. Chem. 2008; 6: 2308-2315. DOI:10.1039/b803258k.
The 4-N-acyl and 4-N-alkyl gemcitabine analogues with silicon-fluoride-acceptor: Application to 18 F-Radiolabeling; Cesar Gonzalez, Andersson Sanchez, Jeffrey Collins, Ksenia Lisova, Jason Thanh Lee, R. Michael Van Dam, M. Alejandro Barbieri, Cheppail Ramachandran, Stanislaw F. Wnuk; Eur. J. Med. Chem. 2018; 314: DOI:10.1016/j.ejmech.2018.02.017.
