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ICG-aniline
Nom chimique: Indocyanine green-ethylaniline // Synonymes: 4-(2-((1E,3E,5E,7E)-7-(3-(6-((4-aminophenethyl)amino)-6-oxohexyl)-1,1-dimethyl-1,3-dihydro-2H-benzo[e]indol-2-ylidene)hepta-1,3,5-trien-1-yl)-1,1-dimethyl-1H-benzo[e]indol-3-ium-3-yl)butane-1-sulfonate
- n° Art.:RL-3360
- Formule:C53H60N4O4S
- Storage temperature:-20°C
- Masse moléculaire:849,13
from 250,00 €
description
ICG-aniline labelling with APEX2 can capture all 13 mitochondrial messenger RNAs while leaving all cytoplasmic RNAs untouched. APEX2-mediated labeling of RNA is thus a promising method for mapping the subcellular transcriptome, which could shed light on their functions in cell physiology. Hence it provides an alternative methodology to the common Biotin-phenol labelling.
Indocyanine green (ICG) is a near-infrared fluorescence imaging dye. Absorption maximum is at 800 nm and there is slight absorption in the visible range, which results in low auto-fluorescence and tissue absorbance. Emission maximum is at 810 nm.
ICG has been approved by the FDA and has been found in numerous applications in therapeutics and diagnostics, like: detection of solid tumors, localization of lymphnodes, visualization of retinal and choroidal vasculature, angiography during reconstructive surgery. ICG can be used as imaging dye and as a hyperthermia agent.
references
Expanding APEX2 Substrates for Spatial-specific Labeling of Nucleic Acids and Proteins in Living Cells; Ying Zhou, Gang Wang, Pengchong Wang, Zeyao Li, Tieqiang Yue, Jianbin Wang, Peng Zou; Angew. Chem. Int. Ed. 2019; DOI: 10.1002/anie.201905949
The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery. Boudewijn E. Schaafsma MD, J. Sven D. Mieog MD, Merlijn Hutteman MSc, Joost R. van der Vorst MD, Peter J.K. Kuppen PhD, Clemens W.G.M. Lwik PhD, John V. Frangioni MD, PhD, Cornelis J.H. van de Velde MD, PhD, Alexander L. Vahrmeijer MD, PhD; Surg. Oncol. 2011; 104: 323-332. DOI: 10.1002/jso.21943.
Degradation kinetics of indocyanine green in aqueous solution. Vishal Saxena, Mostafa Sadoqi, Jun Shao; J. Pharm. Sci. 2003; 92: 2090-2097. DOI: 10.1002/jps.10470.
Stability assessment of indocyanine green within dextran-coated mesocapsules by absor- bance spectroscopy. Mohammad Abbas Yaseen; Jie Yu; Michael S. Wong; Bahman Anvari; Journal of Biomedical Optics 2007; 12(6): 064031. DOI:10.1117/1.2821423.
H-Type Dimer Formation of Fluorophores: A Mechanism of Activatable In Vivo Optical Molecular Imaging. Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke and Hisataka Kobayashi; ACS Chem. Biol. 2009; 4(7): 535-546. DOI: 10.1021/cb900089j.
In vivo Molecular Imaging of Cancer with a Quenching Near-Infrared Florescent Probe Using Conjugates of Monoclonal Antibodies and Indocyanine Green. Mikako Ogawa, Nobuyuki Kosaka, Peter L. Choyke, and Hisataka Kobayashi; Cancer Res. 2009; 69(4): 1268-1272. DOI: 10.1158/0008-5472.
H.W. Rhee, P. Zou, N.D. Udeshi, J.D. Martell, V.K. Mootha, S.A. Carr, A.Y. Ting; Proteomic mapping of mitochondria in living cells via spatially restricted enzymatic tagging; Science 2013; 339: 1328-31. www.sciencemag.org/cgi/content/full/science.1230593/DC1 . DOI: 10.1126/science.1230593.
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