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5HP2O((PEG)2-OH)-(CH2)4-NHS
Nom chimique: 2,5-dioxopyrrolidin-1-yl 5-(2-hydroxy-2-(3-(2-(2-(2-hydroxyethoxy)ethoxy)ethoxy)-3-oxopropyl)-5-oxo-2,5-dihydro-1H-pyrrol-1-yl)pentanoate
- n° Art.:RL-8695
- Formule:C22H32N2O11
- Storage temperature:2-8°C
- Masse moléculaire:500,50 g/mol
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description
5-hydroxy-1,5-dihydro-2H-pyrrol-2-ones (5HP2Os) are next-generation thiol-reactive conjugating groups superior in reactivity and stability to conventional maleimides. Maleimides are prone to hydrolysis, retro-Michael reactions and/or thiol exchange reactions, resulting in antibody and protein conjugates with poor stability. 5HP2O linkers are highly selective for cysteines, yielding conjugates with superior stability.
references
5-Hydroxy-pyrrolone based building blocks as maleimide alternatives for protein bioconjugation and single-site multi-functionalization; E. De Geyter, E. Antonatou, D. Kalaitzakis, S. Smolen, A. Iyer, L. Tack, E. Ongenae, G. Vassilikogiannakis, A. Madder; Chem. Sci. 2021; 12: 5246-5252. https://doi.org/10.1039/d0sc05881e
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All information contained in our webshop is compiled to the best of our knowledge.
Prices and product availability are subject to change and require reconfirmation. Please contact us for further information.
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