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Fmoc-L-Lys(Dabcyl)-OH
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-N-epsilon-4-[4'-(dimethylamino)phenylazo]benzoyl-L-lysine // Synonyms: N-alpha-Fmoc-N-epsilon-Dabcyl)l-L-lysine, Fmoc-Lys(Dabcyl)-OH
- Product code:FAA1498
- CAS No.:146998-27-8
- Formula:C36H37N5O5
- Storage temperature:2-8°C
- Molecular weight:619,73 g/mol
- Purity :min. 97%
- Enantiomeric Purity:min. 99,7%
from €108.00
description
Building block for the SPPS of internally quenched fluorogenic peptide substrates (FRET substrates). The non-fluorescent DABCYL chromophore is able to efficiently quench the fluorescent group EDANS, which can be introduced with Fmoc-Glu(EDANS)-OH (FAA4410).
references
J.W. Drijfhout et al., Proceedings of the 14th American Peptide Symposium, p. 129, P.T.P. Kaumaya and R.S. Hodges, eds., Mayflower Scientific Ltd. England, (1996).
A general method for the preparation of internally quenched fluorogenic protease substrates using solid-phase peptide synthesis. Maggiora L.L., Smith C.W., Zhang Z.Y.; J. Med. Chem. 1992; 35(21): 3727-30.
Visible-light-switchable azobenzenes: Molecular design, supramolecular systems, and applications; M. Gao, D. Kwaria, Y. Norikane, Y. Yue; Natural Sci. 2023; 3(1): e220020. https://doi.org/10.1002/ntls.20220020
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