Fmoc-L-Lys(iNoc)-OH

Chemical name: N-alpha-(9-Fluorenylmethoxycarbonyl)-N-epsilon-pyridylmethoxycarbonyl-L-lysine, Fmoc-L-Lys(isonicotinyloxycarbonyl)-OH // Synonyms: Fmoc-Lys(iNoc)-OH

  • Product code:FAA8775
  • CAS No.:1459694-90-6
  • Formula:C28H29N3O6
  • Storage temperature:2-8°C
  • Molecular weight:503,56 g/mol
  • Purity :min. 98%
  • Enantiomeric Purity:min. 99,7%

from €108.00

Grouped product items
Qty Packing unit Price SKU Availability
500 mg
€108.00
FAA8775.0500
<10 Business days
1 g
€168.00
FAA8775.1000
<10 Business days
5 g
€600.00
FAA8775.5000
<10 Business days
25 g
€2,400.00
FAA8775.9025
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description

This orthogonally side-chain protected Lysine is stable to most reagents used in peptide synthesis. The isonicotinyloxycarbonyl (iNoc)-group can be removed under mild reducing conditions like Zn/AcOH, Pd/C/H2, SmI2 in aq. DMF etc. Isomeric purity >99.9%.


references

Isonicotinyloxycarbonyl a novel amino protecting group for peptide synthesis; D. F. Veber, W. J. Paleveda, Y. C. Lee, R. Hirschmann; J. Org. Chem. 1977; 42(20): 3286-3288. https://doi.org/10.1021/jo00440a018.

Total Synthesis and Structural Characterization of Caveolin-1; H. Hojo, T. Takei, Y. Asahina, N. Okumura, T. Takao, M. So, I. Suetake, T. Sato, A. Kawamoto, Y. Hirabayashi; Angew. Chem. Int. Ed. 2021; 60(25): 13900-13905. https://doi.org/10.1002/anie.202100826.

Chemoenzymatic Synthesis of the Immunoglobulin Domain of Tim-3 Carrying a Complex-Type N-Glycan by Using a One-pot Ligation; Y. Asahina, S. Kamitori, T. Takao, N. Nishi, H. Hojo; Angew. Chem. Int. Ed. 52(37): 9733-9737. https://doi.org/10.1002/anie.201303073.

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