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Fmoc-L-Glu-ODmab
Chemical name: N-alpha-(9-Fluorenylmethyloxycarbonyl)-L-glutamic-acid-4-[N-{1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl}amino] benzyl ester // Synonyms: (S)-4-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-5-((4-((1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino)benzyl)oxy)-5-oxopentanoic acid,1-[[4-[[1-(4,4-Dimethyl-2,6-dioxocyclohexylide ne)-3-methylbutyl]amino]phenyl]methyl] hydrogen N-
- Product code:FAA8550
- CAS No.:172611-75-5
- Formula:C40H44N2O8
- Storage temperature:-20°C
- Molecular weight:680,79 g/mol
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description
ODmab is orthogonal to both acid (TFA) and 20% piperidine-labile protecting groups used in standard peptide chemistry. Dmab esters are cleaved with 2% hydrazine in DMF within minutes.
references
Reference:
A novel 4-aminobenzyl ester-based carboxy-protecting group for synthesis of atypical peptides by Fmoc-But solid-phase chemistry; W. C. Chan, B. W. Bycroft, D. J. Evans, P. D. White; J. Chem. Soc. Chem. Comm. 1995; 21: 2209-2210. https://doi.org/10.1039/c39950002209.
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