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Palm-L-Glu(OSu)-OtBu
Chemical name: N-alpha-Palmitoyl-L-glutamic-acid alpha-t-butyl-gamma-succinimidyl ester // Synonyms: Palm-Glu(OSu)-OtBu, Palm-Glu(NHS)-OtBu, (S)-2-Hexadecanoylamino-pentanedioic acid 5-tert-butyl ester 1-(2,5-dioxo-pyrrolidin-1-yl) ester
- Product code:PAA1000
- CAS No.:204521-63-1
- Formula:C29H50N2O7
- Storage temperature:-20°C
- Molecular weight:538,72 g/mol
- Purity :min. 97%
- Enantiomeric Purity:min. 99,7%
from €200.00
description
Palm-Glu(OSu)-OtBu is used in lipophylic peptide synthesis. It is a part of Liraglutide (Victoza).
Peptide modifier building block for convenient synthesis of Liraglutide and related GLP-1 analogues. Available for research. Several patents have been filed for commercial applications:
US 2015/0073173 A1
EP 2349882 B1
EP 2849882 B1
EP 3127604 B1
EP 944648 B1
WO 2016067271 A1
references
Knudsen, Liselotte Bjerre; Sorensen, Per Olaf; Nielsen, Per Franklin PCT Int. Appl. (1998), WO 9808871 A1;
Knudsen, Liselotte Bjerre; Huusfeldt, Per Olaf; Nielsen, Per Franklin; Pedersen, Freddy Zimmerdahl PCT Int. Appl. (1999), WO 9943706 A1;
Guryanov, Ivan; Bondesan, Alex; Visentini, Dario; Orlandin, Andrea; Biondi, Barbara; Toniolo, Claudio; Formaggio, Fernando; Ricci, Antonio; Zanon, Jacopo; Cabri, Walter Journal of Peptide Science (2016), 22(7), 471-479. DOI:10.1002/psc.2890.
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