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Thomas Bruckdorfer
PharManufacturing2007; 34-41
Abstract: In 2006 the market of modern biopharmaceuticals has reached a volume of over .3 billion in USA and over billion world wide (IMS Health, Inc.). It is projected to grow to an annual value of some billion within the next 5 years. The big ...
Introduction
The Biopharmaceuticals market, estimated at US$ 200 billion globally in 2013 by reportbuyer.com (Biopharmaceuticals - A Global Market Overview, 2013, London), is further projected to reach US$ 500 billion by 2020, growing at 13.5 % CAGR between 2010 and 2020. Among different ...
1. Basics and Principles of Polymer Therapeutics
1.1 Pharmacological Effects
Small drug molecules and also large biomolecules like proteins or antibodies suffer rapid clearance from human body. The concentration of the drug compound drops rapidly as it is removed from the body. Treatment ...
1.2 Polydispersity
The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n ...
1.2 Polydispersity
The polymers in this context are a polymeric linear structures with n repeating units of monomers. Depending whether the polymer is consisting of one single molecular weight (only one n existing) or of a range of compounds with an average mass and a distribution of n ...
Polyglutamates are well known to be highly biocompatible, biodegradable and multifunctional polymers, which have already been used as building blocks in polymer drug conjugates and polymeric micelles. Those systems have been utilized for various medical applications ranging from therapy to ...
2.4 Polysarcosine – a True Alternative to PEG
The PEGylation technology has transformed the fields of bioconjugation, drug delivery and nanomedicine tremendously. PEGylation of surfaces, drugs and biologics has become a multi-billion euro business. However, a heavily crowded patent ...
3. Poly(ethylene glycol) – the Pioneer in Polymer Therapeutics
PEGs show a spectrum of unique physical and chemical properties, which have been described in literature extensively by the pioneers in PEGylation: Harris, Veronese and recently by Hermanson. Here are summarized the most ...
3.2 Amino-PEG-Acids and Active Esters
PEGylation modification with PEG carboxylic acids or PEG active esters is useful for improving water solubility, increasing chemical stability, decreasing aggregation and toxicity, and reduction of immunogenicity. Amino protected amino-PEG-acids can be ...
3.7 PEG-Thiols
3.7.1 Lipoamide-PEGs
Nanotechnology and nanobiotechnology using gold or silver
particles, quantum dots or even magnetic particles are broadly
diverse, rapidly expanding areas of study in medical diagnostics
and therapeutics, sensoric and chemistry. Metal ...