Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Währung
EUR
Schneller Kontakt
Bitte senden Sie mir mehr Informationen über
Mal-L-Dap(Boc)-OH*DCHA
Chemischer Name: N-alpha-MaleimidoN-beta-t-butyloxycarbonyl-L-2,3-diaminopropionic acid dicyclohexylamine // Synonyme: Mal-Dap(Boc)*DCHA, Mal-Dpr(Boc)*DCHA CAS 1491152-23-8 net, Mal-Dap(Boc)-OH*DCHA
- Art-Nr.:MAA1040
- CAS Nr.:2004724-16-5
- Lagertemperatur:2-8°C
- Formel:C12H16N2O6*C12H23N
- Molare Masse:284,27*181,32 g/mol
- Reinheit:min. 99%
- Enantiomerenreinheit:min. 99,7%
Ab 80,00 €
description
Building block, which can be used for conjugation with thiol groups. After removal of the Boc protecting group and conjugation with the mercaptane function the free methylamino side chain will open the maleimide ring under aqueous conditions. While the conjugation reaction between thiol and maleimid is reversible, it turns completely stable in the open ring structure. This becomes particularly important in the formation of conjugates with high value components, like in antibody-drug conjugation (ADC).
references
Self-hydrolyzing maleimides improve the stability and pharmacological properties of antibody-drug conjugates; R.P. Lyon, J.R. Setter, T.D. Bovee, S.O. Doronia, J.H. Hunter, M.E.
Anderson, C.L.Balasubramanian, S.M. Duniho, C.I. Leiske, F. Li, P.D. Senter; Nature Biotechnology. 2014; 32(10): 1059-1062. Doi:10.1038/nbt.2968.
Benötigen Sie weitere Informationen über dieses Produkt?
kontaktieren Sie uns
Broschüren & Flyer
Produkte, die Sie auch interessieren könnten!
