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Boc-L-Thr[Psi(Me,Me)Pro]-OH
Chemischer Name: (4S,5R)-3-(tert-butyloxycarbonyl)-2,2,5-trimethyloxazolidine-4-carboxylic acid // Synonyme: Boc-Thr[Psi(Me,Me)Pro]-OH, N,O-Isopropylidene-N-tert-butoxycarbonyl-L-threonine
- Art-Nr.:PSI1640
- CAS Nr.:143364-85-6
- Lagertemperatur:2-8°C
- Formel:C12H21NO5
- Molare Masse:259,30 g/mol
- Reinheit:min. 99%
- Enantiomerenreinheit:min. 99,7%
Ab 70,00 €
description
Threonine-derived Pseudoproline monomer for SPPS. This building-block can be successfully coupled with many amino-acids using modern coupling techniques avoiding the need for pseudoproline dipeptides and giving the possibility to introduce pseudoprolines in peptides containing non-natural or rare amino-acids. See also the Fmoc-derivative FAA8695.
references
Reference:
Scope and limitations of pseudoprolines as individual amino acids in peptide synthesis; D. A. Senko, N. D. Timofeev, I. E. Kasheverov, I. A. Ivanov; Amino Acids 2021; 53: 665-671. https://doi.org/10.1007/s00726-021-02973-1.
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