Welcome to Iris Biotech
For better service please confirm your country and language we detected.
Currency
EUR
Contacto rápido
Por favor envíeme más información sobre
Boc-L-Sez-OH
Nombre químico: Boc selenazolidine carboxylic acid // Sinónimos: Boc-Sez-OH, (4R)-3-[(tert-butoxy)carbonyl]-1,3-selenazolidine-4-carboxylic acid
- Nº Artículo:BAA4880
- Nº CAS:1841180-44-6
- Fórmula:C9H15NO4Se
- Storage temperature:2-8°C
- Masa molecular:280,19 g/mol
- Pureza:min.98%
from 108,00 €
description
This selenocysteine-derived building-block is used in NCL/deselenization technique. NCL is performed at selenocysteine followed by a selective deselenization reaction, which converts the Sec at the ligation site into Ala in the presence of unprotected Cys residues. Sez is deprotected into Sec by treatment with MeONH2 at pH 4. Sez can also be deprotected using Cu(II) salts. The deselenization reaction is done using TCEP in the presence of DTT.
references
Chemical Synthesis of Proteins with Non-Strategically Placed Cysteines Using Selenazolidine and Selective Deselenization; P. S. Reddy, S. Dery, N. Metanis; Angew. Chem. Int. Ed. 2016; 55(3): 992-995. https://doi.org/10.1002/anie.201509378
Total Synthesis of Glycosylated Human Interferon-gamma; X. Wang, A. S. Ashhurst, L. J. Dowman, E. E. Watson, H. Y. Li, A. J. Fairbanks, M. Larance, A. Kwan, R. J. Payne; Org. Lett. 2020; 22(17): 6863-6867. https://doi.org/10.1021/acs.orglett.0c02401
Copper-Mediated Deprotection of Thiazolidine and Selenazolidine Derivatives Applied to Native Chemical Ligation; N. Naruse, D. Kobayashi, K. Ohkawachi, A. Shigenaga, A. Otaka; J. Org. Chem. 2020; 85(3): 1425-1433. https://doi.org/10.1021/acs.joc.9b02388
Utilizing Copper-Mediated Deprotection of Selenazolidine for Cyclic Peptide Synthesis; Z. Zhao, N. Metanis; J. Org. Chem. 2020; 85(3): 1731-1739. https://doi.org/10.1021/acs.joc.9b02644
¿Necesita más información sobre este producto?
ponerse en contacto
Folletos y volantes
¡Otros productos que también podrían interesarle!
